ASCO 2004 poster

<= /div>

‹date/time›

<= /div>

‹footer›

<= /div>

‹#›

------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/master03.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/preview.wmf Content-Transfer-Encoding: base64 Content-Type: image/x-wmf AQAJAAADXBwAAAEAMRoAAAAABAAAAAMBCAAFAAAACwIAAAAABQAAAAwCzAHBAwkCAAD3AAADAgEA AAAAgAAAAACAAACAgAAAAACAAIAAgAAAgIAAwMDAAMDcwACmyvAABAQEAAgICAAMDAwAERERABYW FgAcHBwAIiIiACkpKQBVVVUATU1NAEJCQgA5OTkA/3yAAP9QUADWAJMAzOz/AO/WxgDn59YAramQ ADMAAABmAAAAmQAAAMwAAAAAMwAAMzMAAGYzAACZMwAAzDMAAP8zAAAAZgAAM2YAAGZmAACZZgAA zGYAAP9mAAAAmQAAM5kAAGaZAACZmQAAzJkAAP+ZAAAAzAAAM8wAAGbMAACZzAAAzMwAAP/MAABm /wAAmf8AAMz/AAAAADMAMwAzAGYAMwCZADMAzAAzAP8AMwAAMzMAMzMzAGYzMwCZMzMAzDMzAP8z MwAAZjMAM2YzAGZmMwCZZjMAzGYzAP9mMwAAmTMAM5kzAGaZMwCZmTMAzJkzAP+ZMwAAzDMAM8wz AGbMMwCZzDMAzMwzAP/MMwAz/zMAZv8zAJn/MwDM/zMA//8zAAAAZgAzAGYAZgBmAJkAZgDMAGYA /wBmAAAzZgAzM2YAZjNmAJkzZgDMM2YA/zNmAABmZgAzZmYAZmZmAJlmZgDMZmYAAJlmADOZZgBm mWYAmZlmAMyZZgD/mWYAAMxmADPMZgCZzGYAzMxmAP/MZgAA/2YAM/9mAJn/ZgDM/2YA/wDMAMwA /wAAmZkAmTOZAJkAmQDMAJkAAACZADMzmQBmAJkAzDOZAP8AmQAAZpkAM2aZAGYzmQCZZpkAzGaZ AP8zmQAzmZkAZpmZAJmZmQDMmZkA/5mZAADMmQAzzJkAZsxmAJnMmQDMzJkA/8yZAAD/mQAz/5kA ZsyZAJn/mQDM/5kA//+ZAAAAzAAzAJkAZgDMAJkAzADMAMwAADOZADMzzABmM8wAmTPMAMwzzAD/ M8wAAGbMADNmzABmZpkAmWbMAMxmzAD/ZpkAAJnMADOZzABmmcwAmZnMAMyZzAD/mcwAAMzMADPM zABmzMwAmczMAMzMzAD/zMwAAP/MADP/zABm/5kAmf/MAMz/zAD//8wAMwDMAGYA/wCZAP8AADPM ADMz/wBmM/8AmTP/AMwz/wD/M/8AAGb/ADNm/wBmZswAmWb/AMxm/wD/ZswAAJn/ADOZ/wBmmf8A mZn/AMyZ/wD/mf8AAMz/ADPM/wBmzP8Amcz/AMzM/wD/zP8AM///AGb/zACZ//8AzP//AP9mZgBm /2YA//9mAGZm/wD/Zv8AZv//AKUAIQBfX18Ad3d3AIaGhgCWlpYAy8vLALKysgDX19cA3d3dAOPj 4wDq6uoA8fHxAPj4+AD/+/AAoKCkAICAgAD/AAAAAP8AAP//AAAAAP8A/wD/AP///wAAAAAAfjEu SlBHAAAEAAAANAIAAAQAAAAHAQMAMRoAAEELIADMAE0AoAAAAAAAywHAAwAAAAAoAAAAoAAAAE0A AAABAAgAAAAAACAwAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAgAAAgAAAAICAAIAAAACAAIAAgIAA AMDAwADA3MAA8MqmAAQEBAAICAgADAwMABEREQAWFhYAHBwcACIiIgApKSkAVVVVAE1NTQBCQkIA OTk5AIB8/wBQUP8AkwDWAP/szADG1u8A1ufnAJCprQAAADMAAABmAAAAmQAAAMwAADMAAAAzMwAA M2YAADOZAAAzzAAAM/8AAGYAAABmMwAAZmYAAGaZAABmzAAAZv8AAJkAAACZMwAAmWYAAJmZAACZ zAAAmf8AAMwAAADMMwAAzGYAAMyZAADMzAAAzP8AAP9mAAD/mQAA/8wAMwAAADMAMwAzAGYAMwCZ ADMAzAAzAP8AMzMAADMzMwAzM2YAMzOZADMzzAAzM/8AM2YAADNmMwAzZmYAM2aZADNmzAAzZv8A M5kAADOZMwAzmWYAM5mZADOZzAAzmf8AM8wAADPMMwAzzGYAM8yZADPMzAAzzP8AM/8zADP/ZgAz /5kAM//MADP//wBmAAAAZgAzAGYAZgBmAJkAZgDMAGYA/wBmMwAAZjMzAGYzZgBmM5kAZjPMAGYz /wBmZgAAZmYzAGZmZgBmZpkAZmbMAGaZAABmmTMAZplmAGaZmQBmmcwAZpn/AGbMAABmzDMAZsyZ AGbMzABmzP8AZv8AAGb/MwBm/5kAZv/MAMwA/wD/AMwAmZkAAJkzmQCZAJkAmQDMAJkAAACZMzMA mQBmAJkzzACZAP8AmWYAAJlmMwCZM2YAmWaZAJlmzACZM/8AmZkzAJmZZgCZmZkAmZnMAJmZ/wCZ zAAAmcwzAGbMZgCZzJkAmczMAJnM/wCZ/wAAmf8zAJnMZgCZ/5kAmf/MAJn//wDMAAAAmQAzAMwA ZgDMAJkAzADMAJkzAADMMzMAzDNmAMwzmQDMM8wAzDP/AMxmAADMZjMAmWZmAMxmmQDMZswAmWb/ AMyZAADMmTMAzJlmAMyZmQDMmcwAzJn/AMzMAADMzDMAzMxmAMzMmQDMzMwAzMz/AMz/AADM/zMA mf9mAMz/mQDM/8wAzP//AMwAMwD/AGYA/wCZAMwzAAD/MzMA/zNmAP8zmQD/M8wA/zP/AP9mAAD/ ZjMAzGZmAP9mmQD/ZswAzGb/AP+ZAAD/mTMA/5lmAP+ZmQD/mcwA/5n/AP/MAAD/zDMA/8xmAP/M mQD/zMwA/8z/AP//MwDM/2YA//+ZAP//zABmZv8AZv9mAGb//wD/ZmYA/2b/AP//ZgAhAKUAX19f AHd3dwCGhoYAlpaWAMvLywCysrIA19fXAN3d3QDj4+MA6urqAPHx8QD4+PgA8Pv/AKSgoACAgIAA AAD/AAD/AAAA//8A/wAAAP8A/wD//wAA////AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAD///////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// /////////////////wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA//////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //8A////////////////////////////////////////////AP//////AAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAA//8AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAP//AP////////// /////////////////////////////////wD//////wD///////////////////////////////// /////////////////wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAP//AP// /////////////////////////////////////////////wD//wD///////////////////////// //////////////////8A//////8A//8AAAAAAAAAAAAAAAAAAAD///////////////////////// //8AAAAAAAAAwsLCwgDCwsLCwgDCwsLCwgDCwsLCwsIAwsLCwsLCAAD//wD/AAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAD///8A//8A//////////////////////////////////////// ////AP//////AP//AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAD/////AAAAAAAAAADC wsIAAAAAwsIAwgAAAMIAAAAAAMLCAAAAAADCwgAA//8A/wDCwsLCAMLCwsLCAMIAAADCAMIAAMLC wgDCwgAAwsIA////AP//AP//AAAAAAAAAAAAAAAAAAAAAP///////////////////wD//////wD/ //8AAAAAAAAAAAAAAAAAAAAAAAAAAAD/AAAAAAAAAAAAAP///wAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAP//AP8AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAP// /wD//wD///8AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA//////8A//////8A//////////////// //////////////////////////////////8AAADCAADCAMLCwgAAAADCwgDCAAAAwgDCAAAAwsIA wgAAAMLCAAD//wD/AMLCwsIAwsLCwsIAwsIAAMIAwgDCwsLCAMIAAADCwgD///8A//8A//////// ////////////////////////////////////AP//////AP//AAAAAAAAAAAAAAAA/wAAAAAAAP8A AAAAAAAAAAAAAP//////AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA//8A /wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA////AP//AP//AAAAAAAAAAAAAAAAAAAA AAD//////////////////wD//////wD//wAAAAAAAAAAAAAAAAD/AAAAAAAAAAAAAAAAAAAAAAD/ /////wAAAAAAAAAAAMLCAMLCwsLCAMLCwsLCAMLCwsLCwgDCwsLCwsIAAP//AP8AwsLCwgDCwsLC wgDCAADCwgDCAMLCwsIAwgAAAMLCAP///wD//wD///////////////////////////////////// //////8A//////8AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAD//wD/AAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAD///8A//8A//8AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAD/////AP////// //////+m////////pv///////////////////////////////////wAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAA//8A/wDCwgAAAAAAwsLCAMLCwsLCAMLCwsLCwgDCwsLCwsIA ////AP//AP///////////////////////////////////////////wD///////////////////// //////////////////////////////////////8AAMLCwsLCwsLCAMIAwsLCAMIAAMLCAMIAAMLC wgDCwsLCwsIAAP//AP8AAAAAAADCAAAAwgDCwgAAwgDCwgAAwsIAwsIAAMLCAP///wD//wD//wD/ AAAAAAAAAAAAAAAAAAD///////////////////8A//////////////////////////////////// ////////////////////////AAAAAAAAwsLCwgDCAADCwgDCwgAAwgDCwgAAwsIAwsIAAMLCAAD/ /wD/AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAD///8A//8A//8A/wAAAAAAAAAAAAAA AAAAAAD/AAAAAAAAAAAA////AP//////AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAwsLCwsLCwsIAwsLCwsIAwsLCwsIAwsLCwsLCAMLCwsLCwgAA//8A//////////// ////////////////////////////////////AP//AP///wD/AAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAA/////wD//////wD//////////////////////////////////////////////////wAA/wAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAD/AP//AP//////pv+m/6b///////////// /6b//6b///+m////pv///wD//wD///////////////////////////////////////////8A//// //8A////AAAAAAAAAAAA//////////////////////////////////8AAP////////////////// /////////////////////////////wD//wD///////////////////////////////////////// //////8A//8A//8AAAAAAAAAAAAAAAAAAAAA////////////////////AP//////AP//AAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAP//////AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAA//8A/////6b//////6b/////////////////////////////////AP//AP// /////////////////////////////////////////wD//////wD//wD/AAAAAAAAAAAAAAAAAAAA AAAA/wAAAAAAAAAAAAD//////wAAAAAAAAAAAAAAAAAAwsIAwsIAAMLCAMIAAADCwgDCAAAAwsIA AP//AP///////////////////////////////////////////////wD//wD//wAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAA//////8A//////8A//////////////////////////////////////// //////////8AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAD//wD///////// //////////////////////////////////////8A//8AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAP//////AP//AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA/wAAAP//AAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA//8A/wAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAA////AP////////////////////////////////////////////////// /////wD//////////////////////////////////////////////////wAAAMIAAMLCwsIAAAAA wsIAwgAAwgDCAMIAAADCwgDCAAAAwsIAAP//AP8AwsLCwgDCwsLCwgDCAAAAwgDCAAAAwsIAwgAA AMLCAP///wD///////////////////////////////////////////////////////8A//8AAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAD///////8AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAD//wD/AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAD///8A//// ////////////////////////////////////////////////////AP////////////////////// ////////////////////////////AAAAwgAAwsLCwgAAAADCwgDCAAAAwsIAAADCAMLCAAAAAADC wgAA//8A/wDCwsLCAMLCwsLCAMIAAADCAMIAAADCwgDCAAAAwsIA////AP//AAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAD//////wD//wAAAAD/AAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAA/////wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAP//AP8AAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAP///wD//wD/AAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAP8A//////8A//8AAAAAAAAAAAAAAAAAAAAAAAAAAP8AAAAAAAAAAAAA//////8A AAAAAADCwsLCAMIAwsLCAMLCAADCwgDCAADCwsIAwsIAAMLCAAD//wD/AMLCwsIAwsLCwsIAwgAA AMIAwgAAAMLCAMIAAADCwgD///8A//8AAMLCwsIAwsLCwsIAwgAAwsLCAAAAAMLCAMIAAADCwgD/ AP//////AP//AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA////AAAAwsLCwsLCwgDC AADCwgDCwsIAAMIAwsIAAMLCAMLCwsLCwgAA//8A/wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAA////AP//AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA/wD//////wD///// /////////////////////////////////////////////wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAP//AP8AwsIAAAAAAMLCwgDCwsLCwgDCwsLCwsIAwsLCwsLCAP///wD/ /wAAwsLCwgDCwsLCwgDCAAAAwsIAwgAAwsIAwgAAAMLCAP8A//////8A//8AAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAP////8AAP//AAAAAAAAAAAAAP8AAAD///////////////////// /////wD//wD/AAAAAAAAwgAAAMIAwsIAAMIAwsIAAMLCAMLCAADCwgD///8A//8AAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAD/AP//////AP////////////////////////////////// ////////////////AAD///////////////////////////////////////////////8A//8A/wAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA////AP//AADCwsLCAMLCwsLCAMIAAMLCwgDC AMLCwgDCAAAAwsIA/wD//////wD///8AAAD/AAAAAAAAAAAAAAD///////////////////////// /wAA////////////////////////////////////////////////AP//AP////+m//+m////pv// /6b//////////////////////////wD//wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AP8A//////8A//////////////////////////////////////////////////8AAP////////// /////////////////////////////////////wD//wD///////////////////////////////// //////////////8A//8AAMLCAAAAAADCwsIAwsLCwsLCAMLCwsLCAMLCwsLCwgD/AP//////AP// /wAAAAAAAAAAAAAAAAAAAAAAAP8AAAAAAAAAAAAAAAAAAP//AAD///////////////////////// //////////////////////8A//8A/////6b//////6b///////////////////////////////// AP//AAAAAAAAAMIAAADCAMLCAADCwgDCAADCwgDCwgAAwsIA/wD//////wD//wAAAAAAAAAAAAAA AAD/AAAAAAAAAAAAAAAAAAAAAAAA/////wAA//////////////////////////////////////// ////////AP//AP///////////////////////////////////////////////wD//wAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAP8A//////8A//8AAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAP////8AAP///////////////////////////////////////////////wD//wD/ //////////////////////////////////////////////8A//8A/////6b/pv+m//////////// //+m//+m////pv///6b/AP//////AP////////////////////////////////////////////// ////AAD///////////////////////////////////////////////8A//8A//////////////// ////////////////////////////////AP//AP////////////////////////////////////// /////wD//////wD//wAAAAAAAAAAAAAAAAAA/wAAAAAAAAAAAAAAAAAAAAAAAP///wAA//////// ////////////////////////////////////////AP//AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAD//wD///+m//////+m//////////////////////////////8A//////8A //8AAAAAAAAAAAAAAP8AAAAAAAAAAAAAAAAA/wAAAAAAAP////8AAP////////////////////// /////////////////////////wD//wD/////AAAAAAAAAAAAAAAAAAAAAAAA//////////////// //8A//8A////////////////////////////////////////////AP//////AP//AAAAAAAAAAAA AAAA/wAAAAAAAAAA/wAAAAAAAAAAAAAA////AAD/AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAA//8A////////////////////////////////////////////////AP//AAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA/wD//////wD///////////////////////////// /////////////////////wAAAMIAAADCAAAAAMIAwsLCwsIAwsLCwsIAwsLCwsIAwsLCwsIAAP// AP////8AAAAAAAAAAAAAAAAAAAAAAP8AAAAAAAAAAAAA/////wD//wAAwsLCwgDCwsLCwgAAAADC wgDCwgAAwsIAwsLCwsLCAP8A//////8A//8AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AP////8AAAAAAAAAAAAAAADCAMIAAMLCAMIAAMLCAMIAAMLCAMIAAMLCAAD//wD//////wAAAAAA AAAAAAAAAAAAAAD/AAAAAAAAAAAAAP////8A//8AAMLCwsLCwsLCwsIAwsLCwsIAwsLCwsLCAMIA AADCwgD/AP//////AP//////////////////////////////////////////////////AAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA//8A//////8AAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAP//AP//AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA/wD///// /wD///8AAAAAAAAAAAAAAAAAAAAAAP///////////////////////wAAAMLCwsLCwsLCwsIAwsLC wsIAwsLCwsIAwsLCwsIAwsLCwsIAAP//AP////8A/////wD///////////////////////////// /////wD//wAAwsLCwgDCwsLCwgAAAADCwgDCAAAAwsIAwsLCwsLCAP8A//////8A//////////// //////////////////////////////////////8AAAAAAAAAAMIAAADCAMIAAADCAMIAwgDCAMIA AADCAMIAAADCAAD//wD/////AAAAAAAA/wAAAAAAAAAAAAAAAAD/AAAAAAAAAP////8A//8AAMLC wsLCwsLCwsIAwsLCwsIAwsLCwsLCAMIAAADCwgD/AP//////AP//AAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAA////////AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA //8A//8A/wAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAD/////AP//AAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAA/wD//////wD//wAAAAAAAAAAAAAAAAAAAAAAAAAAAP8AAAAAAAAA AP///////wAAAAAAAAAAwgAAAMIAwsIAAMIAwgAAAMIAwgAAAMIAwsIAAMIAAP//AP////8AAAAA AAAAAP8AAAAAAAAAAAAAAAAAAAAA/////////wD//wAAwsLCwgDCwsLCwgAAAADCwgDCAAAAwsIA wgAAAMLCAP8A//////8A//8AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA//8AAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAD//wD///////////////////////// //////////////////////8A//8AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAD/AP// ////AP//////////////////////////////////////////////////AAAAwsLCwsLCwsLCwgDC wgDCwgDCAADCwgDCAADCwgDCwgAAwgAA//8A/////wD/AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAD/////AP//AADCwgAAAAAAwsLCAMIAwsLCAMIAAMLCwgDCAADCwsIA/wD//////wD///8AAAAA AAAAAAAAAAAAAAAAAAAAAAAA/wAAAAAAAAAAAP///wAAAMLCwsLCwsLCwsIAwsIAAMIAwsIAAMIA wsIAAMIAwsLCwsIAAP//AP//////AAAAAAAAAAAAAP8AAAAAAAD/AAAAAP8AAAD/AAD//wD//wAA AAAAAADCAAAAwgDCwsLCwgDCwsLCwsIAwsLCwsLCAP8A//////8A//8AAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAD/AAAAAAD///8AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAD//wD/////AAAAAAAAAP8AAAAAAAAAAAAAAAAAAAAAAAAAAAD///8A//8AAMLCwsLCwsLCwsIA wgAAwsIAwsIAAMLCAMLCAADCwgD/AP//////AP//AAAAAAAAAAAAAAAAAAAAAAAA/wAAAAAAAAAA /wAAAAAA////AAD///////////////////////////////////////////////8A//8A//////// ////////////////////////////////////////AP//AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAD//wD//////wD//////////////////////////////////////////////////wAA ////////////////////////////////////////////////AP//AP//AAAAAAD/AAAAAAAAAAAA AAAAAAD//////////////////wD//wD//6b//6b///+m////pv////////////////////////8A //////8A//8AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAP////////8AAP////////////// /////////////////////////////////wD//wD//wAAAAAAAAAAAAAAAAAAAAAAAAAA//////// //////////8A//8A////////////////////////////////////////////AP//////AP//AAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAD/////AAD///8AAAAAAAAAAAAAAAAAAAAAAAAA AAAAAP////////////8A//8A////////////////////////////////////////////////AP// AP//pv//////pv///////////////////////////////wD//////wAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAP//AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAD//wD///////////// //////////////////////////////8A//////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////8AAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAP////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// ////////////AgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgIC AgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgIC AgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAv//////Amtr a2trQmtCa2trQmtra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tr a2tra2tra2tra+Vra+Vr5Wtra2vla2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tr a2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2trawL//////wJra2tra2tra2tra2tr a2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tr a2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tr a2tra2tra2tra2tra2tra2tra2tra2tra2sC//////8Ca2tra2tra0Jra2tra2tra2tra2tra2tr a2tra2tra2tra2tra2tra+Vr5Wvl5Wvla2tra2vl5Wtra2vla2tra+Xla+Vr5Wtr5Wtra2vla+Xl a2vla2vla+Xla+Vra2tr5Wvla+Vr5Wtr5Wtra2vla2tra2tra2tra2tra2tra2tra2tra2tra2tr a2tra2tra2tra2tra2trAv//////Amtra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tr a2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tr a2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tr a2trawL//////wJrQmtra0JrQkJCa2trQmtra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tr a2tra2tra2tra+Vra+Vra2tra+Vra2vla2vla2vla2tra2vla+Vra2tra+Vra2tra2tra2tra2tr a2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2sC//////8C a2tra2trQkJCa2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tr a2tra2tra2tra2tra2tra2tra2tra2tra2tr5Wtra2tra2tra2tra2tra2tra2tra2tra2tra2tr a2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2trAv//////AmtCa2trQkIAQkJr a2tCa2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tr a2sya2tra2tra2tra2tra2sya2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tr a2tra2tra2tra2tra2tra2tra2tra2tra2trawL//////wJra2tra2tCQkJra2tra2tra2tra2tr a2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2trMjIyazJrazIyMmsyazIyMjIyMmtrMmsy MjIyMmsyMmtrMjIyazIyMjIya2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tr a2tra2tra2tra2tra2tra2sC//////8Ca0Jra2tra0Jra2tra2tra2tra2tra2tra2tra2tra2tr a2tra2tra2tra2tra2tra2tra2trazIya2sya2sya2trMjIyazIyMjJrMmsyMmtrMmtrMmsyazJr MmsyazIya2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tr a2tra2trAv//////Amtra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tr a2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tr a2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2trawL///// /wJrQmtra0JCQkJCa2trQmtra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tr a2tra2tra2tra2tra2tra2tra2tra2sya2tra2tra2tra2tra2tra2tra2tra2tra2trMmtra2tr a2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2sC//////8Ca2tra2trQkJC a2tra2tra2tra2tra2tra2tra2tra2tra2trazJrMmsyazIyMjJrMjIyMjJrMjIyazIyMjIyazIy MmsyazIyMmtrMmsyMjIyazIyazJrazIyMjIyazJrMjIyMjIyMjJrMjIyazJrMjIya2tra2tra2tr a2tra2tra2tra2tra2tra2tra2tra2tra2tra2trAv//////Amtra0Jra2tCa2trQmtra2tra2tr a2tra2tra2tra2tra2tra2sya2syMmsyMjIyazIyazJra2trMmsyazIya2syazJrMmtrazJrazJr MjIyMmsyMmsyazJrMmsyazJrazJra2syMmsyazJrMmsyazIya2tra2tra2tra2tra2tra2tra2tr a2tra2tra2tra2tra2tra2trawL//////wJra2tra2tra0Jra2tra2tra2tra2tra2tra2tra2tr a2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tr a2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tra2tr a2tra2tra2sC//////8CAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgIC AgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgIC AgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAgICAv// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// //////////////////////////////////////////////////////////////////////////// ////////////////////////////////////////////////AwAAAAAA ------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/master02.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii"

‹header›

‹date/time›=

‹footer›

‹#›

------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/pres.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/editdata.mso Content-Transfer-Encoding: base64 Content-Type: application/x-mso QWN0aXZlTWltZQAAAfAEAAAA/////wAAA/BEAAAADwCIFzwAAAAAAIkXNAAAAAAAAAAAAAAAAAAA AFgCAAAAAQEAAQEAAAEBAQABAAAAAAAAAPDfAAAAAAAAAAAAAIACAeAAAAvwBAAAABI0Vng= ------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/sound001.wav Content-Transfer-Encoding: base64 Content-Type: audio/wav UklGRtYGAABXQVZFZm10IBAAAAABAAEAESsAABErAAABAAgAZGF0YbIGAACAgICAgICAgICAgICA gICAgICAgICAgICAgICAgIB+gICAgICAgICAgIB+foB+gICAgH6AfoCAgICAfn5+fn5+fn6AfoCA gICAfn6AgICAgICAgICAgICAgICAgICAfoCAgICAgICAgICAfn6AgH5+foCAgICAgICAgICAgICA gICAgICAgICAgICAgICAgICAgICAgICAgICAfn5+gICAgICAgIKCgH58fHx+fn5+gIKGiIaCfnp2 dHZ4enx+goiMjpCMgnp2cm5scnZ8hIiQlJSOiIB8dnRycHB0en6AiJCQioSAfHh2dHZ8fn6ChoaE goKGiIaAenh2dnZ6fH6ChIaMko6KgnhybGhudHqCipKSkIiAenZycnBwcnJ4foiQkpickI58altR VV98nLW7q6WOYklDQ1mEo7G3q4huW0lDWX6Wq7uxknpsbmhdX3KAkp6no5iYlHxdU1VTU2qIhpaU enyQmoiGhIKEeF9fbH6Yqa+Ydl9dZHKKkoaMim5VYnyClquxjm5mZF9dhKuzoaWCZF01PXJymLur jG5qXWp6jJyhiH6UbE1sjJqckIJkcpSemIp4W1tfZnylpZyCWVFmV0tfkrunmqGIeGhbeqG9no6W eFtDSWqIlJSlp5h6eHiEZFNRerHFfF9mSTlXr9O5iE07UW6awdXmv3ZLO09VeIZ+lL2neGpdXVlT fq3JtaeUbE0/cK+1pWxNO0NHcLXm2bWMWykSS2iludXffCUMJTt4u9nkvXRLUVNdnt/myZZiR3J8 imxTbnZ6jq+hfm5mU1tuiJ7Dq3g7GkF6oa+/jj0rQVmSyd27fD0vGDFyx/zyuV8SAAo/fKXV5r2E VzUvQ3qt09XDo2YpFC9wjqG/tZ52Yk1RcoieqaGYmI6KfE89T5azlnRqZGhqnK+rt7WWbEc/R1+M ucPRyYpLFAgzhNPy15xkUUNNcIyns7e3q4ZwVzsxU5rR2cW3kEEODk2at9Xq0XovIz9ieKXHzZZT QU1baHaSpbOroZyIaFlwfn56iJ6KcnaAgHRbXXCMmKu3nnRXT1V0jJqYlIJ4eGRddoh+dnZ4nqeK gHpkX3iOjHpoX26Glp6YiIJyU1FskJqhnI50YmRwhn5fbISIiJyaclFfbF1birWzjnRmXVddfqu3 p4JoV2ZwfKGakIRmV2huaICKiIiho5iAYlVbaHqMo6GWiGxTQ1eOr6ujnoBiWWJueJSllHBkaGp2 jKmtnoZqTTlPdISUq7u1moBdR1FbZHBwfpytr6magmhoaGRweH6GlpyalIx4aF1ZboKQmJyOjIaA dG5yipqOcF1kbHaWr6unhmpRTWJ8jJCamJaSinZkanCAioiKhHp4enqCioiSlop0bGpyfIianph8 X1tyfoKQnJiYkn5qYl9qfIyYo5R6fHhwcH5+gJKelJSMdl1XaHyKjpKOfHp4goKEjoZ8eHyAhHqA iIR6bmRocHiIjJqtp45yXVlmbnSKmJaEgHpqbHyAeoKMioR8fH6EiIaCdnBwbnJ6hoyOlJKEcGhy eHp8hIaAgIB+goaGhoR8eHRyamp0dn6Kjo6Ujn52enx6fICAfHhycnZ+iISGjIqAeHJwcnR6hIyM hoKAgHx8fHZ6goB4dnh8gIaIiIaIhHh0eH5+fn5+fn6AhISCgIB6eHh4eICGioqEgHx6eHp+foKK in5ycnqAfoCEgnx4en5+gIaGhIB8dnR4fICEhIKCgHp4enx+fn6AhIaEgHyAgHx6eHx8fH6AgICA goCAgoCAfnp6fHp6foKGhoSAfn5+fH6AgH58fH6AgIKIhn58fHp6fICCgoB+fHx6fn5+hIiKioR+ enh6enx+gICCgoKCgoKCgoB+fn58fn6AhISCgH58foCCgoCChIKAfHx+foCCgoKCgH6AgoSCfn5+ gICAgICAgIKCgoKAgH5+fn6AgISCgoKCgn5+gIJ+gIB8fHyAgoKCgICAfoCAgH6AgICAgIB+foB+ fn5+gIB+gICAgICAgICAfn5+fnx8foCCgoKAfnx8fnx8foCCgoKAfn5+fHx8fn5+gICAgICAgH58 fHx8foCAgH6AgIB+foCAfn58fHx8fn5+fn6AgH5+fn5+fnx+fn6AgICCgoB+fHp6foCAgIKAfn5+ fn6Afnx8fHx+gIKAgH58fH5+gICCgIB+fn58fHx+fn5+gICCgoB+fHx8fnx+gIKCgHx+fn6Afnx6 fH5+fn6AgICAgH5+fnx8fH5+gICAgIB+fn5+fn6AgoSAfHx+fn5+foB+gICAfn6AAAC= ------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/slide0001.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" ASCO 2004 poster

DATA DESCRIPTION

INTRODUCTION

Evaluation of Number of Target Lesions to Analyze in

Time to Progression by RECIST

Mithat Gönen1, Lawrence Schwartz2, Robert Ford3

Departments of Epidemiology and Biostatistics1, Radiology2 Memorial Sloan-Kettering Cancer Center, New York, NY

3RadPh= arm, Princeton, NJ

=

=

=

=

ABSTRACT

= Background: RECIST criteria were designed to evaluated tumor shrinkage and response to therapy= by measurement of multiple target lesions, evaluation of non targe= t and new lesions. There is considerable controversy surrounding the optimal number of lesions to assess response, with RECIST requiring the measureme= nt of up to 10 target lesions. These guidelines were set up to evaluate the endpoint of best overall response. Increasingly, time to progression has become = an important endpoint in oncology trials. We evaluated the optimal n= umber of lesions to measure to accurately and reproducibly assess tim= e to progression.

= Methods: We evaluated target le= sions metastases in 1205 patients (to be checked) enrolled in three Phas= e III clinical trials. All patients underwent CT at baseline and standard follow up scans until progression. Target lesions were measured unidimensionally and response was assessed according to RECIST by 2 independent Radiologists. A total of 5190 (to be checked) target lesions were assessed. Response was calculated accor= ding to the rules of target lesions (up to 10) by RECIST, utilizing the 2 largest lesions and randomly selecting 2 target lesions.

= Results: Using the 2 largest le= sions, time to progression was concordant in 83% of cases. The 2 Radiologists determined the two same largest lesions in 89% of cases. Since the determination of the largest or the same target lesions is not always possible or performed, a random selection of 2 target lesions demonstrated a = 76% concordance in the time to progression.

= Conclusions: Measurement of time to progressio= n may have a greater degree of variability than measurement of best overall response and therefore measurement of minimal selected lesions will lead to a great variabil= ity in response assessment.

=

=

=

=

CONCLUSIONS

=

=

=

=

METHODS

Three Phase III clinical trials are u= sed for illustration

=

=

=

Response is assessed in three different ways:
All lesions: This serves as the gold standard

1.Largest lesions: Largest two lesions only are considered. Repeated for largest three and f= our. Represents the “best case” scenario since = largest lesions are determined after all lesions are measures and assumes multiple readers would select the same lesions

2.Random lesions: Randomly selected two lesions are considered. Repeated for randomly selected three and four. Represents the “worst case”= scenario since selecti= on of lesions to be included in the response assessment is usually more-informed than random, but may represent the true clinical scenario when lesions are of similar size and Radiologist work independently

<= /div>

=

=

=

=

LARGEST LESIONS

Discrepancy with Gold Standard (months)

8.2=

8.7=

7.2=

8.5=

Average Number of= Lesions Per Patie= nt

1097

685=

307=

105=

Number of Pat= ients

9031

Total

5944

2197

890=

Number of Lesions=

Trial

III

Trial

II

Trial

I

<= /span>

<= /span>

<= /span>

<= /span>

<= /span>

<= /span>

<= /span>

•<= /span>Even in best case scenario two largest lesions (RECIS= T) rule may be discordant as often= as 10%

•<= /span>This percent of discordant cases decreases as greater number of lesions are measured however ther= e is a more variability on effe= ct on the discordance in months

•<= /span>As the number of lesions measured increase, reproducibility of determination of progre= ssion improves =

•<= /span> = Determining time to progression using RECIST has greater variably than determining response.

mulitple solid tumors. While RECIST criteria were established principally time to progression as well.In this study we demonstrate the level of discordance in determining •

Most Common Sites of Disease

9.7%

12.3%

1.6%

9.6%

Mediastinum

24.8%

29.1%

3.9%

35.6%

Lung

8.7%

17.4%

Total

3.2%

28.7%

4.8%

Peritoneum=

9.2%

46.1%

12.6%

Liver

Trial

III

Trial

II

Trial

I

Site

73,308

47,459

15,205

10,644

Number of = Exams

48.7%

59.6%

5.8= %

61.1%

Chest CT

8.7%

44.0%

Total

3.4%

16.3%

4.2%

Pelvic CT<= /span>

36.5%

75.5%

32.7%

Abdominal CT

Trial

III

Tri= al

II<= /span>

Trial

I

Exam

=

=

=

=

Most Common Exam Types

0.8= %

2.0%

9.5%

0.2%

0.5%

4.8%

0.7%

0.9%

5.7%

Tri= al

III=

Trial

Number of Lesions Included

LARGEST LESIONS

Percent Discordant

2.9= 6

2.11

8.2

1.78

3.91

5.69

3.08

2.111

14.54

Tri= al

III=

Trial

Number of Lesions Included

RANDOM LESIONS

Percent Discordant

0.6= %

5.3= %

13.= 3%

0.6%

1.3%

9.5%

0.6%

3.9%

12.3%

Trial

III

Trial

Number of Lesions Included

RANDOM LESIONS

Discrepancy with Gold Standard (months)

2.43

1.41

2.91

2.43

2.07

7.91

2.43

1.38

5.53

Trial

III

Trial

Number of Lesions Included

------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/slide0001.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/slide0001_image001.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlhFQI1AHcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAAAAAAU AjQAgQAAAABmZgCAAAECAwL/VI6py+0Po5y02ouz3rz7D4biSJaHYJjqyrbuC8fyTNcbauf6zvf+ Dwx6cMKi8YhMKpc/IvMJjUqn1KOzis1qt9yu4+oNi8fk8gxsTqvX7PYC7Y7L53QmvI7P6/euO/8P GCgY4TdoeIhYV5jI2OjotfgoOUmZFFmJmalJc7np+QkK0hlKWmr6MHqquhqayvoKO+kaS1s7OGub q6uYsuv7C4gLPEzMJVyMnAx1rNzsLMT8LD1tE019jc1inc3d/bHtHS5eAT5ufv7Wi77OnlHeDs/9 Hk8/PV+Pr3yfzz+83w9Q17+ABGMNLIhQ1cGEDFupawix2cKIFClNrIix0cWMTBwNbewI8s/HkCTx jCyJMs7JlCzVrGwJc8zLmDSNPayJk9HMnDyjoPgJNKjQoUSLGj2KNKnSpUybOn0KNarUqVSrWr2K NavWrVyFFgAAOw== ------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/slide0001_image002.png Content-Transfer-Encoding: base64 Content-Type: image/png iVBORw0KGgoAAAANSUhEUgAAAAEAAAABAQMAAAAl21bKAAAAA3NCSVQBAQF8LneCAAAABlBMVEX/ //8AAABVwtN+AAAAAXRSTlMAQObYZgAAAAFiS0dEAIgFHUgAAAAMY21QUEpDbXAwNzEyAAAAB09t t6UAAAAKSURBVBjTY2AAAAACAAGYY2zXAAAAAElFTkSuQmCC ------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/slide0001_image003.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlhBgABAHcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAAAAAAB AAEAgAAAAAECAwICRAEAOw== ------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/slide0001_image004.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlhAgADAHcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAAAAAAB AAEAgAAAAAECAwICRAEAOw== ------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/slide0001_image005.png Content-Transfer-Encoding: base64 Content-Type: image/png iVBORw0KGgoAAAANSUhEUgAAA+0AAARvAgMAAAAQ9u3dAAAAA3NCSVQCAgLMTMuiAAAADFBMVEUA AAD///////8AAAA4fh26AAAAA3RSTlP//wDXyg1BAAAAAWJLR0QAiAUdSAAAAAxjbVBQSkNtcDA3 MTIAAAAHT223pQAALYRJREFUeNrt3UuynSoUAFDqtF45ijRTjJJKM6Og0qIc5btHfhtEPrJBVGwk 93MuspSNiIBkvWAjZqM/33H1f/eNkd57/BPE/2yfx+P5ZnwhnhljEL/oD9Gn4bnhSjxVBwD87mOP UCf+NXi5Z2p+t3z/A/hO+r54GNY7vP7xL10inoDnSxmedrv0tcczIvGfVXh4c3Rc/KqvCbfHc1ON /2zZeNGn3DfGg2tYJl6y9S8FvS3euYAX4bkKetG0+LfHg+9P4JsGf2u8k/d8vFA/ujXezTr7BL95 Kn5xvmc5Z/4D8X4Kd8ALskJCEk/3+I+L/3MfPH81/oONb5LNNnhWiAc/fgB+KcPTPX5xf9XkTqcN 3jRRPDwJfgPxwsUzk9Lt8Kt/nc/BL/JHPn65C17oRON4TQ7i6Wvwq391ZHfEiy2P3PTTZeJNX6Yu 7/qT+v82vRu4eJX1ery+GST3w6sr3Xk801aLbxGeTfCG5aXO4AXLi3mh8Z+Nqn6nDwKz+GVF23Dx 6ip9Bm++drp5AV5/GrHqa4E3lf15vJFq/C9jHhYvM2s73hi4iOXhGfkP9tqbpj3AgzQGw29aBw+6 oQ/wzMFT8ClzeSe/bSSMjTeVvVOP1+FNfxZmKx8ZzxDwPIQ3Fz2BmOEWeJt57wldLt4cPNuPeQ88 hdnjzjOLTDzosQV4/XGO2NRDxnMfv8DfZuHh7RB4cMN098bYeJA97tZOGfhv6baVBLenm98Bv0Tw PA/PwnjVq7eMjbfZEyfx1PuDnyR1TWAvJUPiQfa8PohMvK0pzG39YtpKA+O/Wkadb5HwuiYAqY+H /8D25w4Pvj3G22udwVM5fG3F7cPG7sMjH9gKOYdfd/jvR9kz8WSHJ+YzEL/9MWZ+0fEEXoi9x+tp vPwDkynTlbfqbjzM1i06nhHmxPxJPHV+I8J4Nh4eNubXc3j7eBLg5bUO4N09jYIHYHw8aPdX6yvx u51z8huOHT2HN9Gi+7Nlt+j3D0yNIrxhbv3x+7uMn3YMPPWZeOPQ3b/E+fMQnhG3o6Q/nu3wYhs3 rFln8SyE3651+sZBEFU1Luv5rRK/++ufK7uAfTce/gP/9hiv2sFmfMZi8Lppr49w1WOsymIfwq9O r90xXpgfU4PnGr9AvBRvv9NNe/0Ih9e0+OrwIohnZHdnEsA72x/l5c6QnAje7KKm3Nfiqf8jst19 +u1T/fFUIY3ht2udwgtTr9QAKi91QfxKvKzpKprTdIryo+4gVF0DENO0t09ta/rxK/H7roWtSjZV nuzHLy+aes4ZxMs5WTpdU4Yqyj0+/iMbIFQlT081Q1k+np2v7yvx+1YOk5dfM0vu96nJkkJVfw7+ pwTp1i04nvy8oA2e6yqPnW6E/lvBFc/HC9COqgj6Svz+WqeGWRA9sKhmmphp61D17cfiQRaWsfCm 3LOqWw+m8TppjXeG6Jxv5NXe0sLTuli8nhdY2YCUV3Ud1T/nWzXt3abiCHgOm+Wq3P+pS32lNmGI dy6e1+Httc69J2GI82FNrUrIrwD+/AMsPLyZD77IQ4E3H5ZZvDcqVeJP76cWb86KvrrZweJoZ96O aSSguWOzcD5hJLzQTRkzTWA5meJ+E3H8v8vwwrQ3ib4u4an9jVs8Snqn8IBnJpHpNmzLaYDc9OZe iIeFztxumpHx7fBiCDxsX1H1o8XN4GPx4IZSV8W2pdFy3r/B45Suk3hbqym8bco9HQ/Xgtjd1LbE M9xK9RRegBvVHb7lvOxh8EfDQasfHEc2PgB+BUNqUUcLJPHLKHi3g63LJkbAMzAZpOnaBiPi+X/2 +TDmqMAkno6A/wgT9pgjgXO3S/Hio2r85Y14omdR0L7VvcabfVZ1Ep5skmwjRFTYX4qvalWcxG+1 nNL3vNbtcn3FsBRZxW9XvM8leL3PqjuJk3iun0PWD4Y7tXuNr7uzr8NL/aX4CwYkCXNbc+YBdPVm eknrFhU4ewNqB930WqrU3b0e6HLJODwQdFfg2aV4M9Wl2zqtzsbN44KafZ/GL/qrS2o8O1jjWjy/ Ar+aJ4I1iZz9a3A7wy6o7nW+63Z9Gg+ne1yAl1f6yhv7s3jnXu4C/KoGaS9X4J3bmb8X4NVaJNfj r9iEXE2oKhen8T277g5yvlRe6W6Mh09OeuOv6LrzcnAdvu3645l5r2xhnMdfcDvjb/3w/qz9AfC1 zat8vH+Ur77WIWwFZ95fxPZdePejmGu2DI/3b13fhnfC/PoLfXgr6Fgqw0PvCNe6IChfn48XXhf9 mHhe0ugtxMNPD3mtK5rNVYD/+OthZO6i5yaKlhQoaN5+4PC7FW2EAOqm1p3MLJQFeOLVeVd03SXz qMZL5GWtCL868TRgE09PZsycYlqAZ9R9OHV+ekdT/PZFXrkvw/trAI22mVZoXj9TIX6tmhvbfDPl Mq/5WYA375ocsKKTm12nJa8FVooXBW2IK/A6a1nFswAv9Mz4Kx7IZ21gcnVW0Jfi2TJwnQcemWYF fSn+uxrzsHUeOCtZncslvbdEViRs2DrPWUwCH88/7gyboTZnUF5ODovwVNYjJf0FPTdnXBo2/qeV o4YEjFnfu4tJLNh4+LKZ8TZ3MQls/KIvIGNe69wV5DPOTwmeL2YpPpr/Vxfhcy70RXgzulzk/1HH zamJcm7pS/AtZ4ffAD9kPWfxMHv4+OVqXwE+I69FgxOGbNoc4TP+4FH4pfAPJj77w6WpT/zE3x8/ 6niEiW+OH7t5WxyVRfgxB2PcFl+7RmZrPOwfQW/loB7N4iopiXeeUWDjMV812gDvPp7Cvq2rnCPj bcWj4FN44rxfFLuVgzslr7hKSuC90U3Yw3CQ+8CR8Xp009IEj7k47oYvTCyBZ+QD1wdAbuJx5Ae+ pVGZwKvXx5nRHrgXeuxHnqXnJo4X5vHU0gKPPdChtLqP47l5P4Fe/I5i5rVgsGTeVngk43gVRObJ JHKjBH2hmcJxkXG8fR2N+4IFpKw6bQiMrTDoo3jTarCLTCPmdHXbEBhbYTMniodvxlvQ8boBRRHT LAuiKB6uCiKPw1/EjHoNKJStbIJoHE/tx/D7MdRCmrhBX5RaFG9/xxvgCWkR9CX6TLzAH4IkDB4z 5aIiGsPDBhM+nhv8gphq0WP0XHzlAg3BPZMGQb+7uRFL5LMRPHzEjdvn8t0IaRH06r0/IN+RQ5uL Rx+YIACeVqd2tMWDKooHmULHc4BHThpk+jzeuU3AHo/DAL7RUzCeKlaX4QlpFfSWlko7G9+g+65t 0Gcc2Kvw3MEv6HS1FHf8sh/FO9/g4pmDRw96He7n8cRNDjV3xN2Q7UwnGm+eXIQXHp7iJ67ekRlL +SI89/ALftq1eOokiYlnHh4z6GXadMtvPKDy8aiVEvE3xLS5PJhb7kfEix2eVqcJ8dv0R5q8wb0G z3f4BS9x/ZrUJXkvGr3Ow79ExbMdHjN1YjI8JJ7sN8TU6fbvtysm0QVzCV4E8LQ6VX8jGQ/gI78r nbmQu/EAHjF5jaepN15k4zGH47AAHv+eni2p3swonjhJ4WWLhDZ0/PcdUzV4Cr6hK9Ymgni89PVu Pqle12gfnjM3FS9XPIhfqtP18STV3x7Hw6cWeLliQTx+0CeLU/ShBQxExLyR8IaOZ6k0E3hqvsbD iwM8rU7Z25KPbOMPKgsX4MjNU3hbqlP2tuRzuwTeLr2ClzV2gEcP+uSDlvjgBFsWES/z5GjDxief L8bH5BQut5S1iUM82i6MjaY+kMin/gotS/wQv6Djaz5gR0Uj3tOxQzx20CcDKTEIUecI8ayQ4w3X nh6kkRp7K0995VtD3Cwdb2g7QcHrNS8RTwqP4BdUfHowSXK8PXY4sgge+3EgrcPrrKaSyd9IbBsL X7Z8csYmovhUbou2dK5T10KGHIw8isfbT9aIvBQe4T1B3v5iG+5ToWo89uJ3JL4h4jNGDqbHaOMW xgD4vzZBzzDwqFuovlvaBH3GgNnOeFjf6fBfQD2A2lkGvxOhI9EZD50GD48I2p68JdyCnc+d8bCE G3yTYbhuB174lrwv3mEavHNI8PAwKTYA3ingFt8i6J0OvINrfl+8o7T4JkHvPGsbAe+Ub4tvEvTg 4SInA+CFc4YtvknQg/r9KNmueFC8Pw6+RdDbpRD5EHjmnGCAbxH09mUrhPwKR1NXvBvaAN90ws3P FZ9fj3dDHuKbBL3etqvq5Xg35B18i6A3e12OlKEft3o1kRvyDr7JlX7btufsBfhWL6XyAhvi2wX9 1r45KE4hfKOpXl7IO/hmQS8HWJTg20xx9ELexbcK+u3Ei3y8aDTF0Qt5F98o6OWJPxqlEMbDH6Id CD+sHXyjoJflqADvtQaxToQf8i6+TdBz/Zy1CG9jBG1pHD/kPXyToFdpHT1kDl7qYNFDG5Phh7yH bxH0zFQo+XgBjz7arKpdULv4BkFvKq+jZmzw5/DUYw1I2YW8h28Q9NyWsQI8PPVYY9B2Ie/j8YOe 68NMSvBbRpDxu5D38fhBb65wR0czjBegNFKcnOxD2sM3CHptK8ODU4+UkX3I+/gGQb/ofZfhzanH utLtQ36Hb3Kll4Yl/IvjilCeISz8PuR3+BZXepVwIV6feqyh5oGA9vHN7ukPRxEedmMxWfiQLvOB kN/hm93Tl+O5PP5I4+wDIb/Htwp6VoxXjzmQLvOBkN/jWwV9pHQf/QnfsoDUnxcK5x2+VdCfwMsh 1zinIBTye3yroCcn8FvU4+BDIR/ANwr6w8SiKyegZSIU8gF8m6C3Dby/BXiOhg8G8x7fJuhNA2+3 KGJiahkOPhjyAXyboDf43QpXubOrqrZgyIfwTYKem76iIjzW44tgyIfwTYKe226zIjzSmqfhUA7g 2wzO0Su0F555nHu6cMiH8G0G50g83xemHf5P5LuTWzjkg/gWQa+IgbK0wzcYrBAO+SC+RdDLlELz yX087rsL9N6DgRzCtwh6qQ6l5+MbvFr+IOSD+AZBL69wQZePx32b1LYdhHwYjx/0Eh8sSD6+wRz+ g5AP4/GDnsuBfiHWDr9kpFe2HYVxEI8f9FyObw0l5uEbvIXyKOTDePyg58crwHr4Bi9fPQr5Azx6 0LNtgTCag9c5wWxgHZzKMB496Nl3TkfWgCSNZ3jNy8MgDuPRg/477DhvcILur8S80hydyTAePegj ARTGC7RCdxzyR3jsoI9QwniOV9kehvwRHjnoRUTi40G+cPDHIXyARw56ETmGYTxeoTsO+SM8ctDH xpMG8QLvSnMc8od43KDnEUcw5rmc5kgR8Mchf4jHDfrYKjdBPPvuFWdtnEgAH+Fxgz72RoYgnshx 2gj4SMgf4nGDPvak1ccvq6kjMKqbSMgf41GDvuCdFhueqWkgCPhIyB/jka/02Xguez1klx8CPha+ h/ims+xi+O3mV41Vri9zsZA/xjedZRfFf8wTOoSBWLGQj+Bxr/TZ+J9T9VcXNgR8LOQj+F5Bv8eb PSLgo8F7jG8T9OnHVbCsVeOjIR/Btwh6ETiSLNTDQJHw0ZCP4RsEPQucgv0TG/uR6v1GQz6Gxw96 HtrX/kGlPdjV+HjoRvD4Qc9Ch5IF7rLV7qorvHjIx/DoQS+Ch3I/OMGOgq7dbTzko3jsoOfBQxkb hFiLj4d8FI8d9OFD2RKfCNwYvkFHnlqEKxNfe1eXCPkoHjnozTXMHx5x+Be1hzwR8nE8btAzXYBy lgv7btU9OYmQj+Nxg57ZmXLukKijP6ieRJsK2ygeN+jtEXRUsZkWdTtMhXwcjxr0oO9eZOGrRyal Qj6Bxwx6DkqPOwb04A+qD3gq5BN4zKCHJxJewyLz6uhas6WDNo7HDHq4BC5svUTOfN0u02cujscM ejh+GvZMHsd8ZaSlYzaBRwx6iBQ5+NrbmvSJS+ARgx4evSx85ZYRsgk8YtA7RceZ6NIGn3HeEnjE oHeH9LfHZ0RsCo8W9O78efDkshU+47Sl8GhB796ltMfnBGwKjxb0vfE5Zy2Fh6Wnqty7A4p5c3xO vCbxLOMIjojPqamTeFh86Hp+8/B2f23wWeGaxIucQzgePquiTuKxgr4zPusSncYjBX1nfFZ5TeOR gr4vPu8KncYjBb2LB70ZTfB5xTWNRwr6vvi8PGfgkYK+Jz6ztGbgkYK+J56j4ZGC3jlwzpIl+HiW d74y8EhB3xMPchxLvRBfUe7h4GPRFi8yT1cOHhai2OcSePinzmI16PjMkM/C88wDmcjRwS4a4DND PgsPS9H5nHbE5+Y3B48T9OLwyQG2PTfk8/AoQd8PnxvyeXicoC9a8bhmyw35PDxO0Bescl63Zec2 C48T9Adjq9Dx+eU0D48S9OxoeAQyPj+zeXiUoD8YX4SOzy+meXiUoD8YWYaNL8hrHt45momPRhLJ WTCkeisopZl4lp9iLJEe+IL6KRMPD+fpzPIuZ77gypSJFwVJFm7I+JLqKROPE/Q98CUXplw8StD3 wJdk9AweO7eoyZUU0Vy8U+PRcfFFlVMuXpQc0axNJ4KLLyqhuXinOKHMPLCvFMHEF2UzG+8cUlqb R07a4MsKaDaeFyWb2kgjfFnVlI13jmltuedJfDI/cU7eRSkb70RT5cniMI0w/mRklZ2hfDxe0DOS gT+VcuE1KR+PFvRe6cHEF/a35eOx7m30DlkMf3YNVFg88z+dxuM8rBVmf03woiiPBXhwVDM+Hd64 LTn6qW0Yf/bwFuXxHJ6ezJo+MVtyTfCsJI8FeFvjnc2ZgPlqg7eZLDhSGXgbTxkfDm4kG39+ZlUj vE2XnsyY3BlV6/0tLh4MxK7Bs4LSWYJnBQf1OAF9zu3SxsoLj+n5NRP4CVDOZ3nBQT1K4LufIzyc dXgaLwpKZwleFHz2CL/tcznA2xxXrJZRUDpL8CXpHhw9amW6Qtd4Bs9XxRv6WH7pLMIXpBvGyz+N 4LW+As9LPZkfLkg3hleTZIN4/Zan83iRf0EqwgskvPzPoN2cbNlmxWnbLT80i/Br1VV+1Sc7jHfu 82vwLDs0T+Ar8kXgfzu8zsxS9wonns0pw+cf1Bw89fFWXzebJ7d0luHzD+o5fH0jco2vJ1+Dzz+o B3ujgK326d7YsMpG5JZw7p+X4de6c+LhdQ4CGarCZ7/9qhBf+VYtB2+SdD9Tj+f5miJ8droHe5N/ HV8YrBqfvaBYIV50wFe/wia797MQX7lEnbpZS62EWPswMPfQleJrml7hDpoAvrJ87d74jIX/1wOP srB9A3zdlovvtE38xPfYQhehiZ/4p+MDu3kNPpyDiZ/4iZ/4iZ/4iX8PvrYv4xZ42aO3w4tuubkQ r7opfXztg5E74AUJ43nlg+A74BkJ43ntU/Dx8Rw8kXPw6hcPxtuhnD5e2R+MN4+hd3jzm4fiibO5 eGNv+kLQMfBUPv4xeGPvlZfueEfo4Fnn034dXgohXmekH/0i/Ec9R93GKjD1JrMLLrkX4L+7UuNQ DZ6/BP8FCx+vLv3UmXHwOPyf7d8dXg9vfDZebnyHZ7ISfANe1fAAr0Y6vROv1o6qGGp+G7y6nG+j T8x1/iV4EcALMPfodXhZ7usGe90Cz/U7WiF++79vN/YleNXMc/GidpLBTfCE/N72xyB+K/fPx/+E vGziufjvfNLn47/vKZVtWgcvKqeX3AO/TaKh5uoGurGejxdbD9bnu28X/1PuO3bjXIPn2zRyQoW8 4Fm86NqHdQ1+m6rCTRe103X9ePy2MxHCV796e3i8Ku2hhxbVL10fHs+1OfCsjvV6VnMVXgU21zt1 n9X1y8cleL0v3UfvPKV9dr+9DvnVrPfnzaWlT8Zz/+Q6eNG1vu+O313L3ZEZ3R5PX4Lf7cofltIt J5eceRrDi55V3gX4+A/6XnV7V3h+jbYfivZgvL8nDy86Vnn98T6N7S593fLSH7/PgfeBB+N307D3 Y29fjO/4yOqaB5VRfL/H1APie+564id+4id+4id+4ie+Jf7Pm/Gdn9SMhu/8iHIwPOnaaT0SXmWi N38sfPdhEqPhO0b/EHjxZrz7bqjX4b/b7zfjdei/FC8HqL0VbxeTeCO+70DE4fDn39n1BHzXXU/8 xE/8xE/8xE/8xE/8xE/8xE/8xFfihf1e0Bfg9SDcL56DJ1Ud1wy5Cs/NPvWDSv2bJ8+0kJudSmse V1F9VB6PBz30+nHVojP0dDxXe6VSC7rrnz3BaNvgYzmNJ/qwPBzvrPr7g2e2BiCPx3ODpwpP1cVO PB8vS7y62n3xHz21hj166dfvZh7Ibf99F4j57l3+8+y5tCtYFYXLdVPkWz+/yyXxvkPSrsDbxuy2 Yo5aGohvpeDZ8+dX+CCWb3j5Ijfx6VzdXbU8FFVffefQATx/+KK/Em93//niZUEgnau7i9bGsjvj EP+G5aHge7I5AXjWfwXaS/EC4Fnn6u6iVdHANy6+87jzK/CQSOgPftFZoe/CMwff137JenhwXwB/ 0WuULsTzBeDpi/Hdp9lcgacH+I55GAMvAL63fQy8DPb+k8tGwHN5Q/Ne/M81/h14+I3Fk/6zKi/H fwDedt9P/Cvw7E14yHsb3ln+6YtfvRcYvgbPP8w8nn0ffgGvdXgDfnG+cRf6fjpewH2xxRuH8nS8 0421vGsQooMnb8M7Xdcvw8NeC/E+PDVf8m+//cS/BQ+7b8Xr8E6nxcvw7tji1+FpQzzPbyKX4UWD 49QCn3mDmId3uhvug7fbCbwIpXNLPNo28RM/8Vh4rOc1d8R/U0ZJT9T6ohttgWfflFHO/f3wiD23 98MzmTTGqb8dXiCmfTs812kvr8LLrmum00Yo93fBb+faXff2JXiVyUVNJF5WpIllN8Azndoi59JS le/l+XiQ2rJNJ130IakP+sHxDKb2xRPwlPrheDd3G96cb4RbvJvhwXQrXl+u7oOXo65tkghv6rsH Xr6MfBuBaX/5dLys6xdm8aCKZ9XV/fj4j55ntI3ABGD+dPwHMLdBiAvI+uvwIEVRfa0bHE8i+PrJ JrfAi1viF2y8+8S6NnV+Zzx9A36deEG829jq9xHfA0/eiac98ZFWE0uIeG+8Mya7Cp9uK6bwuw82 x1MEfGYa2XiVNQw8a4ovyQjW6Zz4M3gy8e/E//fOYv/P5AD+svo6Pzre2dnL8c5d7Ovw0NtxkfMB 8T0zcgHez4FzMHpOPRgB70yufR0eXOg7vqRxDDzsq69/YnM7PH0z3u7dvRK8AA9GZiA8n78b3g5G QRiZcT+83v3zF/re4bm+t+n6Oo9B8Gad585rgw2B1y/x6Z2PMfC2X5y+D28fjXTe9Qh4M6Dg8Uu8 B/AmG/SNeH5FqR8Fv16Si1Hw/IITP86CIaz/4qcXvccGOvVdjdOZ9Wg8fCHnu1ZLYc4l/WV4t0Xz UjzRbyp8E945Am9bEk5uAp7+t+F1w+aVZ17x31ns1d7fth6e3b4B/1b81nH5Vvw35F+LJ+rtpG/E C/1SXrg9fUCScerXMTs/ewme6RdxO8fjHXixv7ERfTtwL8TLUu/gO/deX4iXpR7ie3fdX3tXt0L8 K95poTZV6g1e3+J2zMJ1eFXqNZ7Drq2n43WphyshvuB1zHLTpX6FbzCiffNwGV6XejUs5ZL+rKvw ptRvgxD7h/uleFPqV/2+Oiw7z+cU4TnecTKlfhuBiXneOXgskEg0B++tQoGBt6VejcPDK/OcBLdS /MHSGxh4W+rVUDSMRKN4pA0jn+CypgYk0YrU7oUHpV4PSGoS80PiOQhyPSYHIdl74MlucAJHa+IM vkiQU+rtEu9IBX/w5aHcS5vCo9V5o+OdRJhp5r5icX+n1MPOjOUFeBYcioZV5w2Od9OwHZh4Ledx 8W6pd6ZWYZz6sfHsCA9mWT0WvyVilQCPcrkbGi+8ZLzXMT8bb8cgLju8QGjnjY1f7c3H4uFBB89z 8XD8rf+Iurbg3wBvn9D4Z355AV75Pyv28/mb4L8ZdfH8DRWe3Vw8QWjh3gjvN3Kefp0/xjOM7py7 4lESvymev+rFXR6e3eCVbQgZDOJRqrsb9NsH8Tgn/qZ4ghNRt8RzpMcWt8RjpXxHPFJ1t8PT6K5T ItYHz7AS1viMGErj/UTbvYuaYuFzc5iPL066CI9V3RXuusnpLMajlfob4ZmaWoZW3d0Rz64o9Zfj qRl4TF+HV5MKL6nuRsFfUt0NgndvwfuVgSHwfOJfiv9e8d6LN9++C7+fQv5o/J84vufWH++shvc6 PNzZC/G2Jf9OvLqF/bwV/+W/GE/E2/B+U/ZVePZm/La9Gq8fA7wUv+pey5fit2F4r8VvL2va47vl 5WL8EsD3y8vET/ww+H4vLpv4sfD9VvkfCv95MV69q/J1eA7w4mV4Tl6IZ4teKgbiuz21mPhB8OvE vwavl3ue+LfhZQ58fLeunTHwq3x2p57gTfzEvwnP3olnDp6+Fs/7jUEeBb9o/Pcx1lvx2zDcl+Fl 743OzFPxYgezeDP4+rH43VwajQfjzntl5gK8d2IVnpN34N2dOS/iVgMWnox39ubja/fA8z0leIzj tF/I38VXJQ7wWYcyA8+Iu2Hg/XVveU5ez+Cxtyq8zVoATxHsQ+NttU49PFJFNzTeP/kaX5XsPfDb jZtJihp889c6DIN3GvHYQ9EGXiRI9Vewu+IpBt6+m+59eGJb+W/Crxqvb/BehCfwv3fi1eO4iX8P Xky8wst/A3hRt4th8Z8cfOXxHRWv2vBytNkRvu5l3MPjZTe9PAQ7fOX7De6NJ3W3DzfB68c07kfY Y/Fq5QB2jOfkJXi6x++7tp+DFyk8++6hqltnXPz6L47n9XsYGL/G8dsOlqq0h8eri9wOv534yr7M 4fFyc94/b/Ndmf5d8eyb/FKZ6sC9tzH8lu3qDnx+C7zw8Tjl6p54jpP4PfAreFa3YhX62+BXB89w 7LfEb3mm6PjErtOiLniGlbLC5xSiHLzaRFP8mjpN+fjsDBbgi9Muw4v+qx4X4xvkQH3Bu+sHwvdf 6nwk/Ip0sRsUr57OH+F76zvjSeJnffW98STwM/BN14kW/fGf/c/gd6JnBdQXH2p6eaGAdX8zJt7f VehxVSd9V7wI7WtfCSZvSG6J13tb3J/tPvbIM29uEGkULzqfi24V7F4fGpzQ6WrXvXm762TY41mn kO+P302yCVV4j7zUgV1+7Lf7w9MpNxfgvQvefj28bg3cK25pmVPy9yshdnt72yX4NYp/atte6WSd v4Tx/Ur9FfjviCxxjO9X6i/Abwtcgyrdx3fszuiPVzh+gK8cfzk23nRQ6/68/Ti8Xlm5pHm7xPDs wfPneQp/xes1eu3R7kubd3149Kl4nsL3DPkrOjN+xfCs/y1WL/wW8TyG7/py3v4dmHqmga7U/bG3 /ex98bIDK4bveaHri+fyVi6Gv+Teuss+mey7k2yzkDvEgwvdn4KEb4Jf4nj7atIusd8Z//1Pzqo0 b65gTk/uYnL1MLwq03LYqRmn4A5O+P6Ue53bz8Cr6ZSb0AS3O97ejnh7Gp7agyBC+J+Q77ogYE88 rMzgGKxdZh7Yb2/eVfGzT9CSc0djde1b6Il39hl4YsO9B1lPwpuNH+BZp3ruerzZoTPNhPa0X4J3 x5u97TWNTvF+G57Hn88/G+88gX8b3svBxE/8xE/8xE/8xE/8xE/8xE/8xE/8xE/8xE/8xE/8xE/8 xE/8xE/8xE/8xE/8xE/8xE/8xE/8xE/8xE/8xE/8xE/8xE/8xE/8xE/8xE/8xE/8xE/8xE/8xE/8 xE/8xE/8xE/8xN8fbxYSa7bxXvhDyiG+/TpZ3fCHxqNfdFjyuxv+cBdHeN4+U73wohjPnoPnh6v8 RfCt1wWc+D74Q2T452Tin4J/dbEvx3fI1KD4V1/nn9XCO6Act+2bL//bDc9L2/Ydtm74w23iJ37i r8D3fHfOxE/8xXg28RM/8RM/8RM/8RM/8RM/8RM/8RM/8RM/8RM/8RM/8RM/8RM/8RM/8RPfeyMT P/HvxV9Z60z8xE/8xE/8xE/8xE/8xE/8xL8EL+iL8fzN+AYzYW6DF2/G8wadTe3wAhfPGmSxHT63 gsrEN8iiaIhfMPHfjNL74FlmjObhOcGf+NgSn5lk3ud+Qv4Xdo3XFE8R8YR8+K3weZnNwn8XXhDY eWyKz72G5SVGV+wary1+QcNvz9OwazyLp9h4nvkAMAcvlxvJvX6Mgc9KNAcvQ4gjF8/G+AUJL1PC rvFa4v/LK/cZeLVkjkDOZEO8WPKq0Qy8vnAg13hN8Twr1Qy8LkLINV5TvKyj/1XjzdJSyDVeQ/z6 kbehf6rxTJ955KBvi5ftsmo8MTXnnfBbeU3VUkk8tw3Q28T895T/nLJkx2MS/y0/Knt/cfHU/wJv Y1u+6/HfQs8SiQy3sa1g/UqVqRR+u2DeEb9m3C+m8FsLB70jo/X27b5l6SZuAi+2FLDvabrgefrm JoGXKaD34vTAr+nLSAKvLkTNFwNtgU/35MXxQlUad6vxtncZ1FZ4utK4W42n8bQGr3tE7hb0X7wg yeo+eeZlYncL+u0S9StV7uN43uaepguekeSqzSn8oj52taYcTz5rqtynanv1RapPZLSNbPjUk5vU df5qxcmNbQNpeB2eUe/7m1zz2A+cfiv8Grw3xiH3OdDlG5Owqpj3Wzdt+l1a4OnmTrRMk3d17ncN Rmg02TiVT5loDd69wG/9ebco9/x3zklK4hfnw+Qm9/Y4T2yc6n0r8+OWe9CiS13k8vDOid4SH/cO DwzIEChPaeEtjbxsDnuHJ0CXZd5Y4XTXtU1FtRlGxXNwIc67DU0/tLDlR5WlUa/07MMAPusvCrp6 VFkatU+LwBcy4uBBjceHxn97b8wteN5zxSQeRI/Gj1ndf29DbD235PxJxiNqk87Y+O0GtKz9mTE4 4S74tQHeTlsYG0/K85YxJsceBnlcB63wmuDBYVD4q5kHmfv+W9b2LsNvH06NcXo0/u/Vzhh+aYXv 8GbyofH0amME/80bpyWgInzuxJ0L8b9K+tkK8Yv+crijIFu2vKh/uRCvj6pYCv6sI54V9S8X4e10 4gG7MWVHfVH/ci5+cfEDRv92KSKUF0zXysVvagHwy9XYvWRZxadownfu/PlF4m0H4XB3N1yFe16X fQleD80hhX/XcROqoi94i3buFPJFHgPzaT5eudc91/nVfdGZh0288cq9HjeXXx+V4Rns0KNZf9lv E+S3HDSYfV5O40d8Zie8axISnu3xA7Zz1D1dB/yAT24UPrsvKxf/CeCHO/Uan5ux3EbOZ+cVg4xQ AdlQucwOyOzloUL4EU49HCDGWuHp6rTw8mfoN94YyIbGI8f8qroKQLJ8iMFJzgCxVngm75Y/8C+X Aco9p2t7/BZHThX3U/MPcGPL3F4GmdfcXGUvAynH8VL7k59vBrix/cCaqBV+9Ze02XZ5eYfO1qAF eNoG7/eOCTnbMHc/jbbNaQzqZssfKl6PF16n8BZpl5d7JvFU52nZfpj91wUdXo5UVnZXn/kNzy1e DhfDx3sPqyS+wYqwRRtx8GqUJHrX9cGhECPg7aA72YO5tManZnD02XSr22pIyQjR8/jLL/EBfOGE gLP4FgvhnsEvDr5wKshZ/AAtW4u356FsEtB5fP4+muMXkK2SEnkWP0R9p2oeQcEPSk7KSfwYlb3q qOX0ZHPjNN4tXX+vwpNV3nb0xPt3NFdV/VspZ2dn+53Ee/XdZZOOvn1L4vT6sTj43mOR/+ovVKvm ZF/qSbx3pHu3eBb9hbrRLqvkK/Fefde7uQcu7KrEnwt6FHzuwtpYG7hvk+tXnWxwnsN7lX3vDnyn ilH9GWdycA7vHmhxLZ6uZ28yz+Ip+K77egrO7vYP0hrj3V2x//rihduFHshRS7x3nMnvvnh+Mf7j fNe5W4cF8KdusU/h3bqVfTrjCRwJxnvj3cr++76LnnjxCeBPjYw7hXcak6L3A0u+wKUBrsX/7L0v nl2Kdyt79oH4DotKuCVNqU+t2HcG7y5F8h3mDvGtC4EgTivH4E8kdQbv3MeI7Y7S/KB9a2/D71Y0 6Ihf7DfcfVLdYYzWPyfXvfHOzbNcFBjgf3UYnAiu6mrf+Y9mK/GwZhVycgPA04J5Hnj4U72I52p7 i+Nk9fEd+jY4xJ+YRFuBh+M+mHfm5Rp8rU897EypWJO5dqIQ8YbmMPkU4UxWCjbh4Ol6cvx7JV6o zlODJ14YtMLDB7PL2bZVJZ4TTpwWnhoS1BG/3eCee3BQiWcfbySmwrdu5DpNPLKcfGFyJX4blAru 5/WaIs3xcMWu08uS1mVzu+gR8h/ALzJVmZn6tUUOyjPM9vmFOevwXL7Fjxzha4v/4TLtMNvsdIu6 Ds9UhAM8RcRvjyGD4cycRubZ+rUOLzMG7uQ4Jj7y9lKn7+JUu74aL4yxBT72biuc4d5VeD2Nabec hMGfv94T8/w15Dx5bcPE66pY7PErAl7NjA0lgtOGrMLrww+Xk1A532WR5ydLFV4nGcji9Xhza5uF z70cqZAxoR7uHkBpQ9bgzcxFH6+/d7uYl5w0zUXbXsyCQX85nnmNWvMjDQ3iIy/UYqB2t/jgDTLK 8NcafGBladWzEMRT9bPAxYtSiF9cXXDUxeV4ofcP8R8wABbidW7BLK1/ZoVJc7YtnsfxKBd6lPsv iCfgPgNWcrbdY3o4YVh7P4B/Gxx1MTB+OcRvhcGU7NX8WQS/NrvW4eJ/voD3eAH89iPTCA79MoSn x7scCb8cLSfDAFhk4EF9EazcxsSv4VzrtguY9leHR8g4Np5CgtvlIPGLxfNMPA9f6EfDy9z7jV3w tSrwfzDwdK3dsPFOmqQh/tRQjA54k6934R1hBA8P1d3x3MerzMLLEftg4wM/vBb/qcRbEMAHGzQY HVm4ePW/uZ0HmSbucUni1yS+Pt8D4+MjvDCWHW6L31kcRx0eId+otb1ZJ/QkXhTgMTac56k8H+8s LfYI/OpoxTHeuT1N4MGSAGPjdZPNwYcqb+J068Xw7DZ4raEpPAOnPoy3nX23xGt0CA87rgN48GAS 4pe1yYaKZz6eml8J05ttT/0RfoE/uxueRfCr08Wnf0IegXeyzUJ4sMwBJ3bb4/k98SSGB+U+gHea QHT31ch4WaLNRIwg3qzEHsQvNrG74eV1zAQ1TNu67HSEHX51z7z9izvgt8Hm9mLm4g3AVHm72v4Q 38aOPVbSGUHktuOp/TILb8tKs/GcyAkLOBzyAC9K8c1G8qIfVdCIOcCbUTYBvBMo5iA2at02KFJ2 5NERXj+/z8Q3u8w3HR99hF+z8KvF07XN1hQPO2/P49u9P+IS/K6bPopvN3OhIV6U453csEAf8APw u2nfYbz+1PJefMP5Ok3xgcFYBXj9vLtZqW+MPxhUlIunRS9gGw5vyuxJfNuVp1pe6hiYJaLwf8vw pyeNXY9XeoiX/ftM39gk8I3tjaf/CYDf/vu4+CWJb2lvPvdR9WnpZ3Tq31x8w3jvgVfxbfAbcvdQ w+3vFf7t/m3x8hZX6AKwrPY27QCvr+wFs3KGxa8OXnbvrsf4skXa74WX3bvHeDhc/yn41azZ5wzH fwne7A5cvw7wPXPTFe80eQP4Xuf8EryzfNQe33nrjYez5K7H/w+lkruaTyqbSwAAAABJRU5ErkJg gk== ------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/slide0001_image006.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlhLAAwAHcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAAAAAAs AC8AgAAAAAAAAAKThI+JAewKo1yzWsnmy7f7f3DgqIgkaUbp+QWut4aXS7Ng/djzy8WJX6k1ekCW sPGbtV4hE1NnOEYhxaLlicqOrFfo1rvlYrQ35An71dDW7LXyveiZO+IkeGmztvdSaqtUdxdohzJ4 w8d3p2JYUpaWp0gXSceoM1j5g2mkKIa2Oal5JhmaM6khyiVnSjG1irQxd1EAADs= ------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/slide0001_image007.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlhGAK+AHcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAAAAAAX Ar0AgAAAAAAAAAL/hI+py+0Po5y02ouz3rz7DzJBSJbhaKbqyrbuC8eygs42Wd/6zvf+D9zkgkRR 4IhMKpfMpvMJjUqn1Cqiis1qt1xs8bsagsHHsblSE5/X6rWb0n7zyvL69RC3A/P6PoDv90IX6JZG +AV4WKioM8hIhve4JxmYSHlieSljqLmT2fnzCarhODoXaTojmnqzygrn+nqCKusSW2uLi3OrK0Tb m8ILbCI8jFdsDPebDILM3OE8XPpMvEzNEX2Nkd07rd1s/b0tbsOt602OHZ6uzA5jjovuPm4Az2w/ v4D/Kp+Ptu7Pwb6A9QgaMUgKIMIEAwk2NNVvoUCFEgtWnHXxz8Nn/5wy6vP4YSOoiCBpiax10l3K SyRL/qFYcWU6mZJaluzo0mLODDQf2QSJM2fPb0MV/fQY1GXRa0sJHc2Y9ObOhFCbsooKdCpPpFZT YUWqld7Fp2NhSuyaDK0esjHNLlQrjWvYjzp3wgV2Vw7bs24R5j0ndy7Dvgb/xgss2GRYwygRJ35Z V+jjCYzP7H1L2OFkCZXNXPabOWDnq44Tf4W6OcJoMqudhvbXelRsIp8Lv843u1PuPbvtnC6b+kFv H7U1R1YaXHhpwb/bJm8wvEdx0bfnRfe5fG5zvs9FZF9cXWV371VTb8c8nsZ3redBpx9cfnN72+/v xJ8833j9436vL//in9V+ADrkHxvhsVPgIQmWs+AY+VEnIGRjNQjJgKhFSGEM08F24EwRShhThkU8 yCGG601FIm4fiigIi0GkaN2KJ9rVITku6jWjZBYCJ+CNLGyo4o7O9ZgjckJyR+R9j8EonolKmlaj OD7+N6F5URIl45PMXalNHF18CWaYYjpBXpXycckUdODRZSZ+aFLj5ZrqaandmxypyV6ZIVp5JHps 0vjnWVNKZ+c9eKKop6B8gqhjoEbO2eaShaZ1KKCQ7nlmn+45KhWnhQ16iqb0eQoWqaKB6smkxsSZ p6mwodqIqnEl+ih8kUIpqn6XNmorpm7mCqGrQ/aqaKaM1kossrL/egVrK8t2Uymv9t26JbAlCotk sv0t2mwLrCKKrUrdqvIsYLR2uutb425S7mHnBpjutsauq8K3lmr7KbdyxgsvvgTq22q4m/p7KsDg Cjwqwa8afK/Cw07rq6TWBomwrhAX++ux6PJbKscFz7uvw9lerC7D0pK8Mcr5ghywxzyKLK7Jyrbb WMVS0vsOzbLYe/LETOEsiM78RDuzxitnDHQJPBedNClN/yg0ae92DDOCT4cRtVdEp5y1T1fX27Vs W/er8r8sH+zyw2Eb9XUwa+s2NtVlf4x0yHO/fDdubVfjc5M2X1v1THsr/bYmS3PdN0eD41A4S3Ff mLZ1i2NktNx5/4/cuB9Axpi4h1NDztCYoo9OOhMyI965jdXW3XLgFje8+uRbfY437HWmLuXjtfcs p+xiRe5n67HbnXlNq0tcOeiuByv87cnvjjuWziPv+wWHk21778RH3+XxuD6vdvHYTf999RZcb/kx pa/P/penYy8+I22YDx39vnCfJu3hgy/5++njDyf99e9s2eNf8C4XMwLyzoADQ6DV/Kc8ByZMgjay H1UYOEEKMk+DRLHg7DD4uvgZRYAJZB3algc4DnbJg2JhIQTQF0EAxsOF5xOhgnS3PxrWQ4ftAOEG Vcg54D1QgUXzYQpt+IbN+Y2HU2Oip3ioRAQhsRI4xJwMUeJE1f9MUXNVPOAWLZPFF35xLV1s4Bgd FEblXJFSJDTjGvmRxom8cVZ/oxgKV9i+POqRdGesAwyhB8XxxHFAgzRaILtTyD/m8H/IK2Ai2+i5 5zwSkiE0YvcQuT1LBvGO+ZNkJicpxEgmB5ShrOQhPdm8OeKFkrnDZCo16TdOBtCVJwRiLG15J1o6 cnunHOUnecnI7+0ylb0MDillKcU6dtKXrzxmHxEhyF8SM5jeK6IzVQmRaDYTmDHM2DBriU2x6XKB 14RlLlEJznC6q5StROc3s1fMRb2Td/E01jyZRk3yWZOb0GskOfm5P3/uc5rdFCjqzClKXBpqnANN Zz29+U+C9lNqmBF1aD4zWdByPtSg8FNnzdgpPXdWFJ4XfWVGAWpFiDaUpAWl6ErpWdJ0MlKjMS3g SSUaUNPscac8nUL9egrUoCaBlSH9kFFbesSjKrWSTF2qUxPqxadKVXVInapVV1XTq2r1KkLtKvsK AAA7 ------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/slide0001_image008.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlhBwE+AHcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAAAAAAH AT0AgQAAAAAAAMz/zAECAwL/hI+py+0Po5wy0Iuz3tTyD4Zi5I3miT5lyrYusL7yPMX0jUN2ztN7 D8T9gkTTsIhEHZNMzLIJ1TyjVMa0inVcs9gt92vwgpvicdeMDqfXiTK7534j4/IbvQ6841/6vdBf 1Qc4IzhoBBOQqLjI2Oj4CBkpOUlZSVlhCJUowNnp+QkaKhogWtpJajqaWoq6+nlVmBmy6VqrauvZ iqu7i3uKKZtE6+vLa2vsipxMLAAbLKzMzCodbVptzez8XDQsvZwNHl4MvB3U7Z16PU2sfjtOUk50 jr7OLl6cTR7PM08f2v7vXi92+vYJAYgO4SuBx/LBM8hPIbWJ9hgmKwiRkESL/9/wcUyHMSMfSyRL mjyJ0lJIkS36+Vv4EVtMVitZpnD58hRFjxXf6bDpY2NPngOHHqsJ1IhQokWbOq2lLakLnDmb7XwK 1eFPqVNTev0KNiwjpFxBUM25VGharSrKtlyKtWPcVWrJut1w9uVaow0JPrx7Iq+/vUz7+mwLODBc w4XlzrVmN/EFwfQIP5Z5WItkpVXrNaZ79ejfzWYXZ53p7jPI0aQ5UE4Y+jTfi6xbSxGLO7fuSJFt qzDtmLHw4bS3+sYLHDTqgMtBRT2e4bU3y8SDF0cMPXrydLGte19tPPvk7ZhVl788qrf4NuQ9o2c+ m6769Qekd/9+vjp47PQrtERP/Z5z9+2nWX81/Aefee7pB1ltBjawW4QS5jZff7Fkd6FkGR63IWAd 2vahWyGSNiJXJWr4YIUp1rdieC36N2GMMoZVAAA7 ------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/slide0001_image009.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlhigAeAHcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAEAAACI AB0AgAAAAAAAAAJ5jI+py+0Po5w0gIuz3rz7D4biSI5GiabqyrbA6cbyTHdwjee6ae3+/7sBh0SX sIhMio7KphPDfEqR0ak12LtqgdWtV9b9ilfhsZlUPqs/6bVb037L43I3va6+4836vbjv5wUYqDVI aGV4KJWo6MTYqFQhOUlZaUlZAAA7 ------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/slide0001_image010.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlh+QBcAHcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAAAAAD5 AFsAgQAAAAAAAMz/zAECAwL/hI+py+0Po5w0BYGz3rz764UaKJZk+VXqyrbuC5zo3Ml0Zt9Yfgfw DwwKHzwdqjhDJo0b3/AJjaqUzFoVd8VmndKu9xvL9sRUEzkWSKvX7Lb7DY/L5/Q6vVUWC/IfPb/2 13cVaEV2xkLIlKi1RbY40ugnuYWntxSJWZVm+fjIOHi44knjOVo6upcJakiJaHnEqmq0OanJWatZ +SpSiquI2nkbm4toZ3yMnKysJmzrqxg6tcs77DwILAtdPas7Xbia3YMNHj7WKuotSG6tOc6+rj3Y nQ5ZTurYHG9/Ke9K37RtlqNlBAsaPLgGD8KFDBfmE/gMYj90/+rBk9juoQ53/xd7zKvYK6A4jeZE liRGseIOk/e2cMTY8aSij/9C7jPxciNJneekqVx504zLhkSLNlRoNKnSNzv5BaXWswIqWE9DnGpK laXTmf5+2oyZJKfMd/q4plT5lexGsS21ZkXp06tbodew0q2qDq7Un0DBbp21NLDgOUgHG25oF+pc xXrBOH7sgO3fspQ3Qr6MWYHkt345c8sM+vLmu51Jfw6N+stoxqVZn04NG8rh2YZj236y2mpi05Zv +/6RO29r3VF/G98bsS3eb42PO4cQnPlw4a+fW4+8m3plnhOve19AO/zS7+TLmz+PPr369ezbu38P P778+fTr27+PP7/+/bDF+/8nyl9mU/W13WTcNRegFwOmMh1Ai6WQIGQLBtMgB6VEKOE0FKp1oFkY qqbhchZVOEJh/50YRxi7bFigch4iJ5eIDta1oowEckgKTfSk1eIRE9rIIJB76JgOjzABFiKJN/Zo ApHeGNkhkjUqGSSVQ3aF1oPajTQljp4d2dtZIGkpHWAonkmQk0laWeUvazJJnJBcxJWlkG1K+QqL YEYZJp1j2nlVl3BuOVafMNbJZqB5AmlKNIf+mSg+gu5pYKEeFYNmpppuqoyak1LqIp7ZlWlpqUl4 uiigkqbqJW98XipmTWRauOqotEZa3AQLxtnql1yyOiipr+aIJaS9ukrKj1S9NpqrBJw+C220baBq 661yKnssoaEaSsGu2vpqqo9vgorstrD6KauqLo07LLjmEhvrjrPOmNGn4bpGbpPFposrjcDmy2u2 EIoibcEGo0ltcu8uLK69DOPb7hEJz/uJwICwe2/AwdYwsZwKh4XxwxoDbFXHVjLrb7UjkjzyuY/y a7GwyYZcqbs1S4zpwf7RbDPEGZf8IRjYbkxvzE0ELTTP5S7dMy9Ig+jwzT6LDPTTUgzNsrUnW92F ztJyLUUBADs= ------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/slide0001_image011.gif Content-Transfer-Encoding: base64 Content-Type: image/gif R0lGODlhbgBYAHcAMSH+GlNvZnR3YXJlOiBNaWNyb3NvZnQgT2ZmaWNlACH5BAEAAAAALAAAAABt AFcAgQAAAAAAAMz/zAECAwL/jI6py20N1YtxUgfs3Uzz5H1C+AWZiCJkmYKter6sPNLrZt60a/dy vsPtdBRiJRasDH0vYFLJbBkhzqdj+bMhrYspNZqqciXYpjaATqvX7Lb7DY/L5/T0dqwqS8/4rj7M 18eTRdh01+d1VSh1iJfYAYYiJvjotxjWOFZJdimZUQcaKjpKipbJtTm493NqlZrXKTKJ+CcZKHjw mhsp2/qkWxNb4psErHtMHGTMOwwsxMyB7HyxLBz9WZqtvQ2aXGtrjeMNHU1OPR7+bMY6XfQ9Y9gO le7OjgtLP88o/2VeH39vlz99mPgpytcPYMBq6wxh4wYxIkQAFCtavIgxo8aNxhw7evwIMqTIkSRL mjyJMqXKlSxbunwJM6bMmTRr2ryJM6fOnTx7+vwJNKjQoUSLGj2KNKlSnhKbOiWFrqFUQPYWvitX 9R7DVQq1XlW3L2AwhAfDWh2Y0KxXtGULit1KtSsuuODkUvpK7dZcvP/2Pf0LOE5UrlPrqt3LFlJW xGQV26WV2NJjR3wJegqMObMdg44Ly9J7NzKnyZoqp3V7trHkw6FVj/arOfbTwXE9w2MN2bUq1Gt1 48NNWfTuy29Nt70sO7nEAgA7 ------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/master01.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii"

‹header›

= 249;date/time›

Click to edit Master text styles

Second level

Third level

Fourth level

Fifth level

‹footer›

&#= 8249;#› ------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/master03_stylesheet.css Content-Transfer-Encoding: base64 Content-Type: text/css Ym9keQ0KCXt3aWR0aDo1NTRweDsNCgloZWlnaHQ6MjY0cHg7fQ0KLlRCDQoJe21zby1zcGVjaWFs LWZvcm1hdDpub2J1bGxldFwyMDIyO30NCi5UDQoJe3RleHQtYWxpZ246Y2VudGVyOw0KCWZvbnQt ZmFtaWx5OiJUaW1lcyBOZXcgUm9tYW4iOw0KCWNvbG9yOmJsYWNrOw0KCW1zby1jb2xvci1pbmRl eDozOw0KCWZvbnQtc2l6ZToxNTMlOw0KCW1zby1jaGFyLXdyYXA6MTsNCgltc28ta2luc29rdS1v dmVyZmxvdzoxO30NCi5CQg0KCXttc28tc3BlY2lhbC1mb3JtYXQ6YnVsbGV0XDIwMjI7fQ0KLkIN Cgl7dGV4dC1hbGlnbjpsZWZ0Ow0KCWZvbnQtZmFtaWx5OiJUaW1lcyBOZXcgUm9tYW4iOw0KCWNv bG9yOmJsYWNrOw0KCW1zby1jb2xvci1pbmRleDoxOw0KCWZvbnQtc2l6ZToxMTAlOw0KCW1zby1t YXJnaW4tbGVmdC1hbHQ6NzEyOw0KCW1zby1jaGFyLXdyYXA6MTsNCgltc28ta2luc29rdS1vdmVy ZmxvdzoxO30NCi5CMUINCgl7bXNvLXNwZWNpYWwtZm9ybWF0OmJ1bGxldFwyMDEzO30NCi5CMQ0K CXt0ZXh0LWFsaWduOmxlZnQ7DQoJZm9udC1mYW1pbHk6IlRpbWVzIE5ldyBSb21hbiI7DQoJY29s b3I6YmxhY2s7DQoJbXNvLWNvbG9yLWluZGV4OjE7DQoJZm9udC1zaXplOjk3JTsNCgltc28tbWFy Z2luLWxlZnQtYWx0OjE1NDA7DQoJbXNvLXRleHQtaW5kZW50LWFsdDo5NDg7DQoJbXNvLWNoYXIt d3JhcDoxOw0KCW1zby1raW5zb2t1LW92ZXJmbG93OjE7fQ0KLkIyQg0KCXttc28tc3BlY2lhbC1m b3JtYXQ6YnVsbGV0XDIwMjI7fQ0KLkIyDQoJe3RleHQtYWxpZ246bGVmdDsNCglmb250LWZhbWls eToiVGltZXMgTmV3IFJvbWFuIjsNCgljb2xvcjpibGFjazsNCgltc28tY29sb3ItaW5kZXg6MTsN Cglmb250LXNpemU6ODMlOw0KCW1zby1tYXJnaW4tbGVmdC1hbHQ6MjM3MjsNCgltc28tdGV4dC1p bmRlbnQtYWx0OjE4OTY7DQoJbXNvLWNoYXItd3JhcDoxOw0KCW1zby1raW5zb2t1LW92ZXJmbG93 OjE7fQ0KLkIzQg0KCXttc28tc3BlY2lhbC1mb3JtYXQ6YnVsbGV0XDIwMTM7fQ0KLkIzDQoJe3Rl eHQtYWxpZ246bGVmdDsNCglmb250LWZhbWlseToiVGltZXMgTmV3IFJvbWFuIjsNCgljb2xvcjpi bGFjazsNCgltc28tY29sb3ItaW5kZXg6MTsNCglmb250LXNpemU6NzAlOw0KCW1zby1tYXJnaW4t bGVmdC1hbHQ6MzMyMDsNCgltc28tdGV4dC1pbmRlbnQtYWx0OjI4NDQ7DQoJbXNvLWNoYXItd3Jh cDoxOw0KCW1zby1raW5zb2t1LW92ZXJmbG93OjE7fQ0KLkI0Qg0KCXttc28tc3BlY2lhbC1mb3Jt YXQ6YnVsbGV0XDAwQkI7fQ0KLkI0DQoJe3RleHQtYWxpZ246bGVmdDsNCglmb250LWZhbWlseToi VGltZXMgTmV3IFJvbWFuIjsNCgljb2xvcjpibGFjazsNCgltc28tY29sb3ItaW5kZXg6MTsNCglm b250LXNpemU6NzAlOw0KCW1zby1tYXJnaW4tbGVmdC1hbHQ6NDI2ODsNCgltc28tdGV4dC1pbmRl bnQtYWx0OjM3OTU7DQoJbXNvLWNoYXItd3JhcDoxOw0KCW1zby1raW5zb2t1LW92ZXJmbG93OjE7 fQ0KLk5CDQoJe21zby1zcGVjaWFsLWZvcm1hdDpub2J1bGxldFwyMDIyO30NCi5ODQoJe3RleHQt YWxpZ246bGVmdDsNCglmb250LWZhbWlseToiVGltZXMgTmV3IFJvbWFuIjsNCgljb2xvcjpibGFj azsNCgltc28tY29sb3ItaW5kZXg6MTsNCglmb250LXNpemU6MTIlOw0KCW1zby1jaGFyLXdyYXA6 MTsNCgltc28ta2luc29rdS1vdmVyZmxvdzoxO30NCi5OMUINCgl7bXNvLXNwZWNpYWwtZm9ybWF0 Om5vYnVsbGV0XDIwMjI7fQ0KLk4xDQoJe3RleHQtYWxpZ246bGVmdDsNCglmb250LWZhbWlseToi VGltZXMgTmV3IFJvbWFuIjsNCgljb2xvcjpibGFjazsNCgltc28tY29sb3ItaW5kZXg6MTsNCglm b250LXNpemU6MTIlOw0KCW1zby1jaGFyLXdyYXA6MTsNCgltc28ta2luc29rdS1vdmVyZmxvdzox O30NCi5OMkINCgl7bXNvLXNwZWNpYWwtZm9ybWF0Om5vYnVsbGV0XDIwMjI7fQ0KLk4yDQoJe3Rl eHQtYWxpZ246bGVmdDsNCglmb250LWZhbWlseToiVGltZXMgTmV3IFJvbWFuIjsNCgljb2xvcjpi bGFjazsNCgltc28tY29sb3ItaW5kZXg6MTsNCglmb250LXNpemU6MTIlOw0KCW1zby1jaGFyLXdy YXA6MTsNCgltc28ta2luc29rdS1vdmVyZmxvdzoxO30NCi5OM0INCgl7bXNvLXNwZWNpYWwtZm9y bWF0Om5vYnVsbGV0XDIwMjI7fQ0KLk4zDQoJe3RleHQtYWxpZ246bGVmdDsNCglmb250LWZhbWls eToiVGltZXMgTmV3IFJvbWFuIjsNCgljb2xvcjpibGFjazsNCgltc28tY29sb3ItaW5kZXg6MTsN Cglmb250LXNpemU6MTIlOw0KCW1zby1jaGFyLXdyYXA6MTsNCgltc28ta2luc29rdS1vdmVyZmxv dzoxO30NCi5ONE4NCgl7bXNvLXNwZWNpYWwtZm9ybWF0Om5vYnVsbGV0XDIwMjI7fQ0KLk40DQoJ e3RleHQtYWxpZ246bGVmdDsNCglmb250LWZhbWlseToiVGltZXMgTmV3IFJvbWFuIjsNCgljb2xv cjpibGFjazsNCgltc28tY29sb3ItaW5kZXg6MTsNCglmb250LXNpemU6MTIlOw0KCW1zby1jaGFy LXdyYXA6MTsNCgltc28ta2luc29rdS1vdmVyZmxvdzoxO30NCi5PQg0KCXttc28tc3BlY2lhbC1m b3JtYXQ6bm9idWxsZXRcMjAyMjt9DQouTw0KCXt0ZXh0LWFsaWduOmxlZnQ7DQoJZm9udC1mYW1p bHk6IlRpbWVzIE5ldyBSb21hbiI7DQoJY29sb3I6YmxhY2s7DQoJbXNvLWNvbG9yLWluZGV4OjE7 DQoJZm9udC1zaXplOjI1JTsNCgltc28tY2hhci13cmFwOjE7DQoJbXNvLWtpbnNva3Utb3ZlcmZs b3c6MTt9DQouTzFCDQoJe21zby1zcGVjaWFsLWZvcm1hdDpub2J1bGxldFwyMDIyO30NCi5PMQ0K CXtmb250LWZhbWlseToiVGltZXMgTmV3IFJvbWFuIjsNCglmb250LXNpemU6MjUlOw0KCW1zby1j aGFyLXdyYXA6MTsNCgltc28ta2luc29rdS1vdmVyZmxvdzoxO30NCi5PMkINCgl7bXNvLXNwZWNp YWwtZm9ybWF0Om5vYnVsbGV0XDIwMjI7fQ0KLk8yDQoJe2ZvbnQtZmFtaWx5OiJUaW1lcyBOZXcg Um9tYW4iOw0KCWZvbnQtc2l6ZToyNSU7DQoJbXNvLWNoYXItd3JhcDoxOw0KCW1zby1raW5zb2t1 LW92ZXJmbG93OjE7fQ0KLk8zQg0KCXttc28tc3BlY2lhbC1mb3JtYXQ6bm9idWxsZXRcMjAyMjt9 DQouTzMNCgl7Zm9udC1mYW1pbHk6IlRpbWVzIE5ldyBSb21hbiI7DQoJZm9udC1zaXplOjI1JTsN Cgltc28tY2hhci13cmFwOjE7DQoJbXNvLWtpbnNva3Utb3ZlcmZsb3c6MTt9DQouTzRCDQoJe21z by1zcGVjaWFsLWZvcm1hdDpub2J1bGxldFwyMDIyO30NCi5PNA0KCXtmb250LWZhbWlseToiVGlt ZXMgTmV3IFJvbWFuIjsNCglmb250LXNpemU6MjUlOw0KCW1zby1jaGFyLXdyYXA6MTsNCgltc28t a2luc29rdS1vdmVyZmxvdzoxO30NCi5DQkINCgl7bXNvLXNwZWNpYWwtZm9ybWF0Om5vYnVsbGV0 XDIwMjI7fQ0KLkNCDQoJe2ZvbnQtZmFtaWx5OiJUaW1lcyBOZXcgUm9tYW4iOw0KCWZvbnQtc2l6 ZToxMTAlOw0KCW1zby1jaGFyLXdyYXA6MTsNCgltc28ta2luc29rdS1vdmVyZmxvdzoxO30NCi5D QjFCDQoJe21zby1zcGVjaWFsLWZvcm1hdDpub2J1bGxldFwyMDEzO30NCi5DQjENCgl7Zm9udC1m YW1pbHk6IlRpbWVzIE5ldyBSb21hbiI7DQoJZm9udC1zaXplOjk3JTsNCgltc28tbWFyZ2luLWxl ZnQtYWx0Ojk0ODsNCgltc28tdGV4dC1pbmRlbnQtYWx0Ojk0ODsNCgltc28tY2hhci13cmFwOjE7 DQoJbXNvLWtpbnNva3Utb3ZlcmZsb3c6MTt9DQouQ0IyQg0KCXttc28tc3BlY2lhbC1mb3JtYXQ6 bm9idWxsZXRcMjAyMjt9DQouQ0IyDQoJe2ZvbnQtZmFtaWx5OiJUaW1lcyBOZXcgUm9tYW4iOw0K CWZvbnQtc2l6ZTo4MyU7DQoJbXNvLW1hcmdpbi1sZWZ0LWFsdDoxODk2Ow0KCW1zby10ZXh0LWlu ZGVudC1hbHQ6MTg5NjsNCgltc28tY2hhci13cmFwOjE7DQoJbXNvLWtpbnNva3Utb3ZlcmZsb3c6 MTt9DQouQ0IzQg0KCXttc28tc3BlY2lhbC1mb3JtYXQ6bm9idWxsZXRcMjAxMzt9DQouQ0IzDQoJ e2ZvbnQtZmFtaWx5OiJUaW1lcyBOZXcgUm9tYW4iOw0KCWZvbnQtc2l6ZTo3MCU7DQoJbXNvLW1h cmdpbi1sZWZ0LWFsdDoyODQ0Ow0KCW1zby10ZXh0LWluZGVudC1hbHQ6Mjg0NDsNCgltc28tY2hh ci13cmFwOjE7DQoJbXNvLWtpbnNva3Utb3ZlcmZsb3c6MTt9DQouQ0I0Qg0KCXttc28tc3BlY2lh bC1mb3JtYXQ6bm9idWxsZXRcMDBCQjt9DQouQ0I0DQoJe2ZvbnQtZmFtaWx5OiJUaW1lcyBOZXcg Um9tYW4iOw0KCWZvbnQtc2l6ZTo3MCU7DQoJbXNvLW1hcmdpbi1sZWZ0LWFsdDozNzk1Ow0KCW1z by10ZXh0LWluZGVudC1hbHQ6Mzc5NTsNCgltc28tY2hhci13cmFwOjE7DQoJbXNvLWtpbnNva3Ut b3ZlcmZsb3c6MTt9DQouQ1RCDQoJe21zby1zcGVjaWFsLWZvcm1hdDpub2J1bGxldFwyMDIyO30N Ci5DVA0KCXtmb250LWZhbWlseToiVGltZXMgTmV3IFJvbWFuIjsNCglmb250LXNpemU6MTUzJTsN Cgltc28tY2hhci13cmFwOjE7DQoJbXNvLWtpbnNva3Utb3ZlcmZsb3c6MTt9DQouSEJCDQoJe21z by1zcGVjaWFsLWZvcm1hdDpidWxsZXRcMjAyMjt9DQouSEINCgl7Zm9udC1mYW1pbHk6IlRpbWVz IE5ldyBSb21hbiI7DQoJZm9udC1zaXplOjk3JTsNCgltc28tbWFyZ2luLWxlZnQtYWx0OjcxMjsN Cgltc28tY2hhci13cmFwOjE7DQoJbXNvLWtpbnNva3Utb3ZlcmZsb3c6MTt9DQouSEIxQg0KCXtt c28tc3BlY2lhbC1mb3JtYXQ6YnVsbGV0XDIwMTM7fQ0KLkhCMQ0KCXtmb250LWZhbWlseToiVGlt ZXMgTmV3IFJvbWFuIjsNCglmb250LXNpemU6ODMlOw0KCW1zby1tYXJnaW4tbGVmdC1hbHQ6MTU0 MDsNCgltc28tdGV4dC1pbmRlbnQtYWx0Ojk0ODsNCgltc28tY2hhci13cmFwOjE7DQoJbXNvLWtp bnNva3Utb3ZlcmZsb3c6MTt9DQouSEIyQg0KCXttc28tc3BlY2lhbC1mb3JtYXQ6YnVsbGV0XDIw MjI7fQ0KLkhCMg0KCXtmb250LWZhbWlseToiVGltZXMgTmV3IFJvbWFuIjsNCglmb250LXNpemU6 NzAlOw0KCW1zby1tYXJnaW4tbGVmdC1hbHQ6MjM3MjsNCgltc28tdGV4dC1pbmRlbnQtYWx0OjE4 OTY7DQoJbXNvLWNoYXItd3JhcDoxOw0KCW1zby1raW5zb2t1LW92ZXJmbG93OjE7fQ0KLkhCM0IN Cgl7bXNvLXNwZWNpYWwtZm9ybWF0OmJ1bGxldFwyMDEzO30NCi5IQjMNCgl7Zm9udC1mYW1pbHk6 IlRpbWVzIE5ldyBSb21hbiI7DQoJZm9udC1zaXplOjYxJTsNCgltc28tbWFyZ2luLWxlZnQtYWx0 OjMzMjA7DQoJbXNvLXRleHQtaW5kZW50LWFsdDoyODQ0Ow0KCW1zby1jaGFyLXdyYXA6MTsNCglt c28ta2luc29rdS1vdmVyZmxvdzoxO30NCi5IQjRCDQoJe21zby1zcGVjaWFsLWZvcm1hdDpidWxs ZXRcMDBCQjt9DQouSEI0DQoJe2ZvbnQtZmFtaWx5OiJUaW1lcyBOZXcgUm9tYW4iOw0KCWZvbnQt c2l6ZTo2MSU7DQoJbXNvLW1hcmdpbi1sZWZ0LWFsdDo0MjY4Ow0KCW1zby10ZXh0LWluZGVudC1h bHQ6Mzc5NTsNCgltc28tY2hhci13cmFwOjE7DQoJbXNvLWtpbnNva3Utb3ZlcmZsb3c6MTt9DQou UUJCDQoJe21zby1zcGVjaWFsLWZvcm1hdDpidWxsZXRcMjAyMjt9DQouUUINCgl7Zm9udC1mYW1p bHk6IlRpbWVzIE5ldyBSb21hbiI7DQoJZm9udC1zaXplOjgzJTsNCgltc28tbWFyZ2luLWxlZnQt YWx0OjcxMjsNCgltc28tY2hhci13cmFwOjE7DQoJbXNvLWtpbnNva3Utb3ZlcmZsb3c6MTt9DQou UUIxQg0KCXttc28tc3BlY2lhbC1mb3JtYXQ6YnVsbGV0XDIwMTM7fQ0KLlFCMQ0KCXtmb250LWZh bWlseToiVGltZXMgTmV3IFJvbWFuIjsNCglmb250LXNpemU6NzAlOw0KCW1zby1tYXJnaW4tbGVm dC1hbHQ6MTU0MDsNCgltc28tdGV4dC1pbmRlbnQtYWx0Ojk0ODsNCgltc28tY2hhci13cmFwOjE7 DQoJbXNvLWtpbnNva3Utb3ZlcmZsb3c6MTt9DQouUUIyQg0KCXttc28tc3BlY2lhbC1mb3JtYXQ6 YnVsbGV0XDIwMjI7fQ0KLlFCMg0KCXtmb250LWZhbWlseToiVGltZXMgTmV3IFJvbWFuIjsNCglm b250LXNpemU6NjElOw0KCW1zby1tYXJnaW4tbGVmdC1hbHQ6MjM3MjsNCgltc28tdGV4dC1pbmRl bnQtYWx0OjE4OTY7DQoJbXNvLWNoYXItd3JhcDoxOw0KCW1zby1raW5zb2t1LW92ZXJmbG93OjE7 fQ0KLlFCM0INCgl7bXNvLXNwZWNpYWwtZm9ybWF0OmJ1bGxldFwyMDEzO30NCi5RQjMNCgl7Zm9u dC1mYW1pbHk6IlRpbWVzIE5ldyBSb21hbiI7DQoJZm9udC1zaXplOjU1JTsNCgltc28tbWFyZ2lu LWxlZnQtYWx0OjMzMjA7DQoJbXNvLXRleHQtaW5kZW50LWFsdDoyODQ0Ow0KCW1zby1jaGFyLXdy YXA6MTsNCgltc28ta2luc29rdS1vdmVyZmxvdzoxO30NCi5RQjRCDQoJe21zby1zcGVjaWFsLWZv cm1hdDpidWxsZXRcMDBCQjt9DQouUUI0DQoJe2ZvbnQtZmFtaWx5OiJUaW1lcyBOZXcgUm9tYW4i Ow0KCWZvbnQtc2l6ZTo1NSU7DQoJbXNvLW1hcmdpbi1sZWZ0LWFsdDo0MjY4Ow0KCW1zby10ZXh0 LWluZGVudC1hbHQ6Mzc5NTsNCgltc28tY2hhci13cmFwOjE7DQoJbXNvLWtpbnNva3Utb3ZlcmZs b3c6MTt9DQouVGJsQg0KCXttc28tc3BlY2lhbC1mb3JtYXQ6bm9idWxsZXRcMjAyMjt9DQouVGJs DQoJe3RleHQtYWxpZ246bGVmdDsNCglmb250LWZhbWlseToiVGltZXMgTmV3IFJvbWFuIjsNCglj b2xvcjpibGFjazsNCgltc28tY29sb3ItaW5kZXg6MTsNCglmb250LXNpemU6MTAwJTsNCgltc28t bWFyZ2luLWxlZnQtYWx0OjcxMjsNCgltc28tY2hhci13cmFwOjE7DQoJbXNvLWtpbnNva3Utb3Zl cmZsb3c6MTt9DQouVGJsMUINCgl7bXNvLXNwZWNpYWwtZm9ybWF0Om5vYnVsbGV0XDIwMTM7fQ0K LlRibDENCgl7Zm9udC1mYW1pbHk6IlRpbWVzIE5ldyBSb21hbiI7DQoJZm9udC1zaXplOjg5JTsN Cgltc28tbWFyZ2luLWxlZnQtYWx0OjE1NDA7DQoJbXNvLXRleHQtaW5kZW50LWFsdDo5NDg7DQoJ bXNvLWNoYXItd3JhcDoxOw0KCW1zby1raW5zb2t1LW92ZXJmbG93OjE7fQ0KLlRibDJCDQoJe21z by1zcGVjaWFsLWZvcm1hdDpub2J1bGxldFwyMDIyO30NCi5UYmwyDQoJe2ZvbnQtZmFtaWx5OiJU aW1lcyBOZXcgUm9tYW4iOw0KCWZvbnQtc2l6ZTo3NSU7DQoJbXNvLW1hcmdpbi1sZWZ0LWFsdDoy MzcyOw0KCW1zby10ZXh0LWluZGVudC1hbHQ6MTg5NjsNCgltc28tY2hhci13cmFwOjE7DQoJbXNv LWtpbnNva3Utb3ZlcmZsb3c6MTt9DQouVGJsM0INCgl7bXNvLXNwZWNpYWwtZm9ybWF0Om5vYnVs bGV0XDIwMTM7fQ0KLlRibDMNCgl7Zm9udC1mYW1pbHk6IlRpbWVzIE5ldyBSb21hbiI7DQoJZm9u dC1zaXplOjY0JTsNCgltc28tbWFyZ2luLWxlZnQtYWx0OjMzMjA7DQoJbXNvLXRleHQtaW5kZW50 LWFsdDoyODQ0Ow0KCW1zby1jaGFyLXdyYXA6MTsNCgltc28ta2luc29rdS1vdmVyZmxvdzoxO30N Ci5UYmw0Qg0KCXttc28tc3BlY2lhbC1mb3JtYXQ6bm9idWxsZXRcMDBCQjt9DQouVGJsNA0KCXtm b250LWZhbWlseToiVGltZXMgTmV3IFJvbWFuIjsNCglmb250LXNpemU6NjQlOw0KCW1zby1tYXJn aW4tbGVmdC1hbHQ6NDI2ODsNCgltc28tdGV4dC1pbmRlbnQtYWx0OjM3OTU7DQoJbXNvLWNoYXIt d3JhcDoxOw0KCW1zby1raW5zb2t1LW92ZXJmbG93OjE7fQ0KLmRlZmF1bHRCDQoJe21zby1zcGVj aWFsLWZvcm1hdDpub2J1bGxldFwyMDIyO30NCi5kZWZhdWx0DQoJe3RleHQtYWxpZ246anVzdGlm eTsNCglmb250LWZhbWlseToiT3B0aW1hIEJsYWNrIjsNCglmb250LXdlaWdodDpub3JtYWw7DQoJ Zm9udC1zdHlsZTpub3JtYWw7DQoJdGV4dC1kZWNvcmF0aW9uOm5vbmU7DQoJdGV4dC1zaGFkb3c6 bm9uZTsNCgl0ZXh0LWVmZmVjdDpub25lOw0KCW1zby1mYXJlYXN0LWhpbnQ6bm87DQoJbGF5b3V0 LWZsb3c6aG9yaXpvbnRhbDsNCgljb2xvcjpibGFjazsNCgltc28tY29sb3ItaW5kZXg6MTsNCglm b250LXNpemU6MjQlOw0KCW1zby10ZXh0LXJhaXNlOjAlOw0KCW1zby1saW5lLXNwYWNpbmc6IjAg MCAwIjsNCgltc28tbWFyZ2luLWxlZnQtYWx0OjA7DQoJbXNvLXRleHQtaW5kZW50LWFsdDowOw0K CW1zby1jaGFyLXdyYXA6MTsNCgltc28ta2luc29rdS1vdmVyZmxvdzoxOw0KCWRpcmVjdGlvbjps dHI7DQoJbXNvLXdvcmQtd3JhcDoxOw0KCW1zby12ZXJ0aWNhbC1hbGlnbi1zcGVjaWFsOmJhc2Vs aW5lOw0KCW1zby1hbnNpLWxhbmd1YWdlOkVOLVVTO30NCmE6bGluaw0KCXtjb2xvcjojQ0NDQ0ZG ICFpbXBvcnRhbnQ7fQ0KYTphY3RpdmUNCgl7Y29sb3I6IzMzMzNDQyAhaW1wb3J0YW50O30NCmE6 dmlzaXRlZA0KCXtjb2xvcjojQjJCMkIyICFpbXBvcnRhbnQ7fQ0K ------=_NextPart_01C8B689.216633E0 Content-Location: file:///C:/2671D4AF/ASCO_files/filelist.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C8B689.216633E0--